ID   GFRP_XENTR              Reviewed;          84 AA.
AC   Q6NVA8; Q28DT4;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=GTP cyclohydrolase 1 feedback regulatory protein;
DE            Short=GFRP;
DE   AltName: Full=GTP cyclohydrolase I feedback regulatory protein;
GN   Name=gchfr; ORFNames=TGas035n12.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase
CC       1. {ECO:0000250}.
CC   -!- SUBUNIT: Homopentamer. Forms a complex with GCH1 where a GCH1
CC       homodecamer is sandwiched by two GFRP homopentamers (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GFRP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR848610; CAJ83559.1; -; mRNA.
DR   EMBL; BC068218; AAH68218.1; -; mRNA.
DR   RefSeq; NP_998880.1; NM_213715.1.
DR   RefSeq; XP_017951683.1; XM_018096194.1.
DR   AlphaFoldDB; Q6NVA8; -.
DR   SMR; Q6NVA8; -.
DR   STRING; 8364.ENSXETP00000046573; -.
DR   PaxDb; Q6NVA8; -.
DR   DNASU; 407953; -.
DR   Ensembl; ENSXETT00000046573; ENSXETP00000046573; ENSXETG00000021554.
DR   GeneID; 407953; -.
DR   KEGG; xtr:407953; -.
DR   CTD; 2644; -.
DR   Xenbase; XB-GENE-974499; gchfr.
DR   eggNOG; ENOG502S4A0; Eukaryota.
DR   HOGENOM; CLU_195651_0_0_1; -.
DR   InParanoid; Q6NVA8; -.
DR   OMA; MWANRIC; -.
DR   OrthoDB; 1560576at2759; -.
DR   PhylomeDB; Q6NVA8; -.
DR   TreeFam; TF329303; -.
DR   Reactome; R-XTR-1474151; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000021554; Expressed in liver and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0044549; F:GTP cyclohydrolase binding; IBA:GO_Central.
DR   GO; GO:0009890; P:negative regulation of biosynthetic process; IEA:InterPro.
DR   GO; GO:0043105; P:negative regulation of GTP cyclohydrolase I activity; IBA:GO_Central.
DR   Gene3D; 3.30.1410.10; -; 1.
DR   InterPro; IPR036717; GFRP_sf.
DR   InterPro; IPR009112; GTP_CycHdrlase_I_reg.
DR   PANTHER; PTHR16852; PTHR16852; 1.
DR   Pfam; PF06399; GFRP; 1.
DR   SUPFAM; SSF69761; SSF69761; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Membrane; Nucleus; Reference proteome.
FT   CHAIN           1..84
FT                   /note="GTP cyclohydrolase 1 feedback regulatory protein"
FT                   /id="PRO_0000189680"
SQ   SEQUENCE   84 AA;  9492 MW;  3EA38993BFC5904F CRC64;
     MPYVLISTQI RMETGPTIVG DEFSDTQLMA QLEADKRTVL GNNFSEYCVN EPPRVTLNKL
     EKLGYRVVSM TGVGQTLVWC LHKE