GFY_HUMAN
ID GFY_HUMAN Reviewed; 518 AA.
AC I3L273;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Golgi-associated olfactory signaling regulator;
DE AltName: Full=Golgi protein in olfactory neurons;
DE Short=Goofy;
DE Flags: Precursor;
GN Name=GFY;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: Required for proper function of the olfactory system. May be
CC involved in establishing the acuity of olfactory sensory signaling (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type I membrane protein {ECO:0000250}.
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DR EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS58672.1; -.
DR RefSeq; NP_001182185.1; NM_001195256.1.
DR RefSeq; XP_011524601.1; XM_011526299.2.
DR AlphaFoldDB; I3L273; -.
DR SMR; I3L273; -.
DR STRING; 9606.ENSP00000459439; -.
DR GlyGen; I3L273; 5 sites.
DR iPTMnet; I3L273; -.
DR PhosphoSitePlus; I3L273; -.
DR BioMuta; GFY; -.
DR MassIVE; I3L273; -.
DR MaxQB; I3L273; -.
DR PaxDb; I3L273; -.
DR PeptideAtlas; I3L273; -.
DR PRIDE; I3L273; -.
DR DNASU; 100507003; -.
DR Ensembl; ENST00000576655.5; ENSP00000459439.1; ENSG00000261949.7.
DR Ensembl; ENST00000610896.3; ENSP00000478493.1; ENSG00000261949.7.
DR GeneID; 100507003; -.
DR KEGG; hsa:100507003; -.
DR MANE-Select; ENST00000610896.3; ENSP00000478493.1; NM_001195256.2; NP_001182185.1.
DR UCSC; uc021uxm.1; human.
DR CTD; 100507003; -.
DR GeneCards; GFY; -.
DR HGNC; HGNC:44663; GFY.
DR HPA; ENSG00000261949; Tissue enhanced (brain, testis).
DR MIM; 618696; gene.
DR neXtProt; NX_I3L273; -.
DR OpenTargets; ENSG00000261949; -.
DR VEuPathDB; HostDB:ENSG00000261949; -.
DR eggNOG; ENOG502RMAY; Eukaryota.
DR GeneTree; ENSGT00730000111841; -.
DR HOGENOM; CLU_040045_0_0_1; -.
DR InParanoid; I3L273; -.
DR OMA; IHKPPKP; -.
DR OrthoDB; 795288at2759; -.
DR PhylomeDB; I3L273; -.
DR PathwayCommons; I3L273; -.
DR BioGRID-ORCS; 100507003; 12 hits in 982 CRISPR screens.
DR GenomeRNAi; 100507003; -.
DR Pharos; I3L273; Tdark.
DR PRO; PR:I3L273; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; I3L273; protein.
DR Bgee; ENSG00000261949; Expressed in cortical plate and 18 other tissues.
DR GO; GO:0030173; C:integral component of Golgi membrane; ISS:UniProtKB.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0097499; P:protein localization to non-motile cilium; IEA:Ensembl.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Olfaction; Reference proteome;
KW Sensory transduction; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..518
FT /note="Golgi-associated olfactory signaling regulator"
FT /id="PRO_0000424823"
FT TOPO_DOM 20..409
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 431..518
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 38..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..501
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 518 AA; 56104 MW; 5D292F2EEF388453 CRC64;
MKSFSRILFL VFLLAGLRSK AAPSAPLPLG CGFPDMAHPS ETSPLKGASE NSKRDRLNPE
FPGTPYPEPS KLPHTVSLET FPLDFTEPLN PDLRETPHPE SPETPKADSL TTSISESLDM
PKTNLSKMAH PESSETPTPG PTEMPHPGSP ETPKPNFSKT SRPEFPETPN TDLMQTTPQE
SPEILQLNAT EVSQAELPET SNTNPTKTPD PKSPEKHDLN STETPNSEFL QALHPDPSKT
PHPESHVTHN PSPTEISQTE FPTTYYQNAT DVPRTSDPQI STSLYPETPV PFKDDATALN
ELSLNPKPGT PAAIQPDSPK LPTSDSPGMV ELKAPQNSGP KESNVPPPSA RIAGPPALPG
RPSQLAPATL RAPQRHSRGE GVNTIIVVER VKETGVTLVG RPRGAAGGAL CLFFAGTALL
IGIFVLLWCL YRRAARQRPF AHHRLPDDGD EPVLHLDAPK DPYDLYFYAP DTWVPSHIAT
KQPPPTPPLP PKLPPPPRGG RPQRLEALSP ATLPNNFV
