GG12C_HUMAN
ID GG12C_HUMAN Reviewed; 117 AA.
AC A1L429; A6NHF1; B7ZL74;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=G antigen 12B/C/D/E;
DE Short=GAGE-12B;
DE Short=GAGE-12C;
DE Short=GAGE-12D;
DE Short=GAGE-12E;
GN Name=GAGE12B;
GN and
GN Name=GAGE12C;
GN and
GN Name=GAGE12D;
GN and
GN Name=GAGE12E;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GAGE FAMILY.
RX PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA Gjerstorff M.F., Ditzel H.J.;
RT "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT newly identified members.";
RL Tissue Antigens 71:187-192(2008).
CC -!- INTERACTION:
CC A1L429; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-10172187, EBI-10172181;
CC A1L429; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-10172187, EBI-745707;
CC -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC large variety of tumors whereas in normal tissues, expression is
CC restricted to germ cells. These genes organized in clustered repeats,
CC have a high degree of predicted sequence identity, but differ by
CC scattered single nucleotide substitution. Their sequences contain
CC either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC by cytotoxic T-cells.
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC sequences, but the high identity of the GAGE members made impossible to
CC separate products of paralogous genes from polymorph products.
CC PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC identified genes and their products. GAGE12B is present as fragment in
CC GRCh37 reference genome assembly due to an unsequenced gap between two
CC clusters in the GAGE locus. {ECO:0000305}.
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DR EMBL; AC142497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC130374; AAI30375.1; -; mRNA.
DR EMBL; BC143615; AAI43616.1; -; mRNA.
DR EMBL; BC143619; AAI43620.1; -; mRNA.
DR CCDS; CCDS43943.1; -.
DR CCDS; CCDS43945.1; -.
DR CCDS; CCDS48113.1; -.
DR RefSeq; NP_001091878.1; NM_001098408.1.
DR RefSeq; NP_001091888.1; NM_001098418.1.
DR RefSeq; NP_001120671.1; NM_001127199.1.
DR RefSeq; NP_001120817.1; NM_001127345.1.
DR AlphaFoldDB; A1L429; -.
DR BioGRID; 609823; 1.
DR BioGRID; 609829; 3.
DR BioGRID; 609832; 1.
DR BioGRID; 935801; 1.
DR IntAct; A1L429; 2.
DR STRING; 9606.ENSP00000371117; -.
DR iPTMnet; A1L429; -.
DR PhosphoSitePlus; A1L429; -.
DR BioMuta; GAGE12B; -.
DR jPOST; A1L429; -.
DR MassIVE; A1L429; -.
DR MaxQB; A1L429; -.
DR PaxDb; A1L429; -.
DR PeptideAtlas; A1L429; -.
DR Antibodypedia; 66732; 27 antibodies from 6 providers.
DR Antibodypedia; 75828; 7 antibodies from 4 providers.
DR Antibodypedia; 77265; 3 antibodies from 2 providers.
DR DNASU; 729428; -.
DR Ensembl; ENST00000381698.5; ENSP00000371117.3; ENSG00000216649.5.
DR Ensembl; ENST00000405679.4; ENSP00000384214.3; ENSG00000227488.3.
DR Ensembl; ENST00000420398.3; ENSP00000397103.2; ENSG00000237671.4.
DR GeneID; 100132399; -.
DR GeneID; 729422; -.
DR GeneID; 729428; -.
DR GeneID; 729431; -.
DR KEGG; hsa:100132399; -.
DR KEGG; hsa:729422; -.
DR KEGG; hsa:729428; -.
DR KEGG; hsa:729431; -.
DR MANE-Select; ENST00000381698.5; ENSP00000371117.3; NM_001098418.3; NP_001091888.1.
DR MANE-Select; ENST00000405679.4; ENSP00000384214.3; NM_001127199.3; NP_001120671.1.
DR MANE-Select; ENST00000420398.3; ENSP00000397103.2; NM_001098408.3; NP_001091878.1.
DR UCSC; uc004doc.5; human.
DR CTD; 100132399; -.
DR CTD; 729422; -.
DR CTD; 729428; -.
DR CTD; 729431; -.
DR DisGeNET; 100132399; -.
DR DisGeNET; 729422; -.
DR DisGeNET; 729428; -.
DR DisGeNET; 729431; -.
DR GeneCards; GAGE12B; -.
DR GeneCards; GAGE12C; -.
DR GeneCards; GAGE12D; -.
DR GeneCards; GAGE12E; -.
DR HGNC; HGNC:26779; GAGE12B.
DR HGNC; HGNC:28402; GAGE12C.
DR HGNC; HGNC:31904; GAGE12D.
DR HGNC; HGNC:31905; GAGE12E.
DR HPA; ENSG00000216649; Tissue enriched (testis).
DR HPA; ENSG00000227488; Tissue enriched (testis).
DR HPA; ENSG00000237671; Tissue enriched (testis).
DR MIM; 300727; gene.
DR MIM; 300728; gene.
DR MIM; 300729; gene.
DR neXtProt; NX_A1L429; -.
DR PharmGKB; PA145148775; -.
DR VEuPathDB; HostDB:ENSG00000216649; -.
DR VEuPathDB; HostDB:ENSG00000227488; -.
DR VEuPathDB; HostDB:ENSG00000237671; -.
DR eggNOG; ENOG502SZ68; Eukaryota.
DR GeneTree; ENSGT00940000153097; -.
DR HOGENOM; CLU_150116_0_0_1; -.
DR InParanoid; A1L429; -.
DR OrthoDB; 1575904at2759; -.
DR PhylomeDB; A1L429; -.
DR TreeFam; TF340669; -.
DR PathwayCommons; A1L429; -.
DR SignaLink; A1L429; -.
DR BioGRID-ORCS; 100132399; 6 hits in 43 CRISPR screens.
DR BioGRID-ORCS; 729422; 6 hits in 123 CRISPR screens.
DR BioGRID-ORCS; 729428; 6 hits in 52 CRISPR screens.
DR BioGRID-ORCS; 729431; 3 hits in 29 CRISPR screens.
DR Pharos; A1L429; Tdark.
DR PRO; PR:A1L429; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A1L429; protein.
DR Bgee; ENSG00000216649; Expressed in cortical plate and 67 other tissues.
DR Genevisible; A1L429; HS.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 1.
DR Pfam; PF05831; GAGE; 1.
DR SMART; SM01379; GAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..117
FT /note="G antigen 12B/C/D/E"
FT /id="PRO_0000311977"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 117 AA; 12925 MW; C35ED8CEB9D1DD07 CRC64;
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC QDPAAAQEGE
DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC
