ID   GG12F_HUMAN             Reviewed;         117 AA.
AC   P0CL80; Q66I50;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=G antigen 12F;
DE            Short=GAGE-12F;
GN   Name=GAGE12F;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Chondrosarcoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- SUBUNIT: Forms tetramers. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P0CL80-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P0CL80-2; Sequence=VSP_040953;
CC   -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC       large variety of tumors whereas in normal tissues, expression is
CC       restricted to germ cells. These genes organized in clustered repeats,
CC       have a high degree of predicted sequence identity, but differ by
CC       scattered single nucleotide substitution. Their sequences contain
CC       either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC       by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
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DR   EMBL; AC142497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC081536; AAH81536.1; -; mRNA.
DR   CCDS; CCDS43946.1; -. [P0CL80-1]
DR   RefSeq; NP_001091875.1; NM_001098405.2. [P0CL80-1]
DR   RefSeq; NP_001091879.1; NM_001098409.1. [P0CL80-1]
DR   RefSeq; NP_001468.1; NM_001477.1. [P0CL80-1]
DR   RefSeq; NP_066946.1; NM_021123.2. [P0CL80-1]
DR   AlphaFoldDB; P0CL80; -.
DR   BioGRID; 108852; 1.
DR   BioGRID; 117808; 3.
DR   BioGRID; 570130; 6.
DR   BioGRID; 755635; 1.
DR   iPTMnet; P0CL80; -.
DR   PhosphoSitePlus; P0CL80; -.
DR   BioMuta; GAGE12F; -.
DR   DMDM; 332313379; -.
DR   jPOST; P0CL80; -.
DR   MassIVE; P0CL80; -.
DR   MaxQB; P0CL80; -.
DR   PeptideAtlas; P0CL80; -.
DR   PRIDE; P0CL80; -.
DR   Antibodypedia; 70742; 15 antibodies from 7 providers.
DR   DNASU; 100008586; -.
DR   DNASU; 2579; -.
DR   DNASU; 26748; -.
DR   DNASU; 645073; -.
DR   Ensembl; ENST00000440137.2; ENSP00000404123.1; ENSG00000236362.9. [P0CL80-1]
DR   Ensembl; ENST00000639028.1; ENSP00000491865.1; ENSG00000236362.9. [P0CL80-1]
DR   GeneID; 100008586; -.
DR   GeneID; 2579; -.
DR   GeneID; 26748; -.
DR   GeneID; 645073; -.
DR   KEGG; hsa:100008586; -.
DR   KEGG; hsa:2579; -.
DR   KEGG; hsa:26748; -.
DR   KEGG; hsa:645073; -.
DR   MANE-Select; ENST00000440137.2; ENSP00000404123.1; NM_001098405.3; NP_001091875.1.
DR   MANE-Select; ENST00000445148.2; ENSP00000416249.1; NM_001098409.4; NP_001091879.1.
DR   CTD; 100008586; -.
DR   CTD; 2579; -.
DR   CTD; 26748; -.
DR   CTD; 645073; -.
DR   DisGeNET; 100008586; -.
DR   DisGeNET; 2579; -.
DR   DisGeNET; 26748; -.
DR   DisGeNET; 645073; -.
DR   GeneCards; GAGE12F; -.
DR   HGNC; HGNC:31906; GAGE12F.
DR   HPA; ENSG00000236362; Tissue enriched (testis).
DR   MIM; 300730; gene.
DR   neXtProt; NX_P0CL80; -.
DR   VEuPathDB; HostDB:ENSG00000236362; -.
DR   HOGENOM; CLU_150116_0_0_1; -.
DR   InParanoid; P0CL80; -.
DR   PhylomeDB; P0CL80; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; P0CL80; -.
DR   SignaLink; P0CL80; -.
DR   BioGRID-ORCS; 100008586; 3 hits in 61 CRISPR screens.
DR   BioGRID-ORCS; 2579; 3 hits in 24 CRISPR screens.
DR   BioGRID-ORCS; 26748; 3 hits in 92 CRISPR screens.
DR   BioGRID-ORCS; 645073; 3 hits in 35 CRISPR screens.
DR   Pharos; P0CL80; Tdark.
DR   PRO; PR:P0CL80; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; P0CL80; protein.
DR   Bgee; ENSG00000236362; Expressed in right testis and 73 other tissues.
DR   Genevisible; P0CL80; HS.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..117
FT                   /note="G antigen 12F"
FT                   /id="PRO_0000311978"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         69..110
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_040953"
SQ   SEQUENCE   117 AA;  12978 MW;  365ED8D41361C7AD CRC64;
     MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
     DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC