ID   GG12H_HUMAN             Reviewed;         117 AA.
AC   A6NDE8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=G antigen 12H;
DE            Short=GAGE-12H;
GN   Name=GAGE12H;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
CC   -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC       large variety of tumors whereas in normal tissues, expression is
CC       restricted to germ cells. These genes organized in clustered repeats,
CC       have a high degree of predicted sequence identity, but differ by
CC       scattered single nucleotide substitution. Their sequences contain
CC       either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC       by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
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DR   EMBL; AC142497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS43948.1; -.
DR   RefSeq; NP_001091880.1; NM_001098410.1.
DR   AlphaFoldDB; A6NDE8; -.
DR   STRING; 9606.ENSP00000371141; -.
DR   iPTMnet; A6NDE8; -.
DR   PhosphoSitePlus; A6NDE8; -.
DR   BioMuta; GAGE12H; -.
DR   jPOST; A6NDE8; -.
DR   MassIVE; A6NDE8; -.
DR   MaxQB; A6NDE8; -.
DR   PaxDb; A6NDE8; -.
DR   PeptideAtlas; A6NDE8; -.
DR   PRIDE; A6NDE8; -.
DR   ProteomicsDB; 905; -.
DR   TopDownProteomics; A6NDE8; -.
DR   Antibodypedia; 57026; 55 antibodies from 10 providers.
DR   DNASU; 729442; -.
DR   Ensembl; ENST00000381722.2; ENSP00000371141.1; ENSG00000224902.6.
DR   GeneID; 729442; -.
DR   KEGG; hsa:729442; -.
DR   MANE-Select; ENST00000381722.2; ENSP00000371141.1; NM_001098410.3; NP_001091880.1.
DR   UCSC; uc004doh.5; human.
DR   CTD; 729442; -.
DR   GeneCards; GAGE12H; -.
DR   HGNC; HGNC:31908; GAGE12H.
DR   HPA; ENSG00000224902; Tissue enriched (testis).
DR   MIM; 300732; gene.
DR   neXtProt; NX_A6NDE8; -.
DR   PharmGKB; PA145148780; -.
DR   VEuPathDB; HostDB:ENSG00000224902; -.
DR   eggNOG; ENOG502SZ68; Eukaryota.
DR   GeneTree; ENSGT00940000153097; -.
DR   HOGENOM; CLU_150116_0_0_1; -.
DR   InParanoid; A6NDE8; -.
DR   OMA; GEPAAQC; -.
DR   OrthoDB; 1575904at2759; -.
DR   PhylomeDB; A6NDE8; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; A6NDE8; -.
DR   BioGRID-ORCS; 729442; 31 hits in 555 CRISPR screens.
DR   GenomeRNAi; 729442; -.
DR   Pharos; A6NDE8; Tdark.
DR   PRO; PR:A6NDE8; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; A6NDE8; protein.
DR   Bgee; ENSG00000224902; Expressed in testis and 30 other tissues.
DR   Genevisible; A6NDE8; HS.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..117
FT                   /note="G antigen 12H"
FT                   /id="PRO_0000339404"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   117 AA;  12924 MW;  C35ED8C0B7D1D309 CRC64;
     MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC QDPAAAQKGE
     DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC