ID   GG12I_HUMAN             Reviewed;         117 AA.
AC   P0CL82; Q66I50;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=G antigen 12I;
DE            Short=GAGE-12I;
GN   Name=GAGE12I;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   GAGE FAMILY.
RX   PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA   Gjerstorff M.F., Ditzel H.J.;
RT   "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT   newly identified members.";
RL   Tissue Antigens 71:187-192(2008).
RN   [3]
RP   SUBUNIT.
RX   PubMed=20546897; DOI=10.1016/j.pep.2010.05.010;
RA   Gjerstorff M.F., Besir H., Larsen M.R., Ditzel H.J.;
RT   "Expression, purification and characterization of the cancer-germline
RT   antigen GAGE12I: a candidate for cancer immunotherapy.";
RL   Protein Expr. Purif. 73:217-222(2010).
CC   -!- SUBUNIT: Forms tetramers. {ECO:0000269|PubMed:20546897}.
CC   -!- INTERACTION:
CC       P0CL82; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-10196803, EBI-10172181;
CC       P0CL82; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-10196803, EBI-745707;
CC   -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC       large variety of tumors whereas in normal tissues, expression is
CC       restricted to germ cells. These genes organized in clustered repeats,
CC       have a high degree of predicted sequence identity, but differ by
CC       scattered single nucleotide substitution. Their sequences contain
CC       either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC       by cytotoxic T-cells.
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC   -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC       sequences, but the high identity of the GAGE members made impossible to
CC       separate products of paralogous genes from polymorph products.
CC       PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC       identified genes and their products. {ECO:0000305}.
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DR   EMBL; BX649339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001091875.1; NM_001098405.2.
DR   RefSeq; NP_001091879.1; NM_001098409.1.
DR   RefSeq; NP_001468.1; NM_001477.1.
DR   RefSeq; NP_066946.1; NM_021123.2.
DR   AlphaFoldDB; P0CL82; -.
DR   BioGRID; 108852; 1.
DR   BioGRID; 117808; 3.
DR   BioGRID; 570130; 6.
DR   BioGRID; 755635; 1.
DR   IntAct; P0CL82; 2.
DR   iPTMnet; P0CL82; -.
DR   PhosphoSitePlus; P0CL82; -.
DR   BioMuta; HGNC:4105; -.
DR   DMDM; 332313381; -.
DR   jPOST; P0CL82; -.
DR   MassIVE; P0CL82; -.
DR   MaxQB; P0CL82; -.
DR   PRIDE; P0CL82; -.
DR   Antibodypedia; 64945; 131 antibodies from 19 providers.
DR   Antibodypedia; 70742; 15 antibodies from 7 providers.
DR   DNASU; 100008586; -.
DR   DNASU; 2579; -.
DR   DNASU; 26748; -.
DR   DNASU; 645073; -.
DR   GeneID; 100008586; -.
DR   GeneID; 2579; -.
DR   GeneID; 26748; -.
DR   GeneID; 645073; -.
DR   KEGG; hsa:100008586; -.
DR   KEGG; hsa:2579; -.
DR   KEGG; hsa:26748; -.
DR   KEGG; hsa:645073; -.
DR   MANE-Select; ENST00000440137.2; ENSP00000404123.1; NM_001098405.3; NP_001091875.1.
DR   MANE-Select; ENST00000445148.2; ENSP00000416249.1; NM_001098409.4; NP_001091879.1.
DR   UCSC; uc004dof.5; human.
DR   CTD; 100008586; -.
DR   CTD; 2579; -.
DR   CTD; 26748; -.
DR   CTD; 645073; -.
DR   DisGeNET; 100008586; -.
DR   DisGeNET; 2579; -.
DR   DisGeNET; 26748; -.
DR   DisGeNET; 645073; -.
DR   GeneCards; GAGE12I; -.
DR   HGNC; HGNC:4105; GAGE12I.
DR   HPA; ENSG00000215269; Group enriched (retina, stomach).
DR   HPA; ENSG00000236362; Tissue enriched (testis).
DR   neXtProt; NX_P0CL82; -.
DR   VEuPathDB; HostDB:ENSG00000215269; -.
DR   VEuPathDB; HostDB:ENSG00000236362; -.
DR   GeneTree; ENSGT00940000153097; -.
DR   HOGENOM; CLU_150116_0_0_1; -.
DR   InParanoid; P0CL82; -.
DR   OrthoDB; 1575904at2759; -.
DR   PhylomeDB; P0CL82; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; P0CL82; -.
DR   SignaLink; P0CL82; -.
DR   BioGRID-ORCS; 100008586; 3 hits in 61 CRISPR screens.
DR   BioGRID-ORCS; 2579; 3 hits in 24 CRISPR screens.
DR   BioGRID-ORCS; 26748; 3 hits in 92 CRISPR screens.
DR   BioGRID-ORCS; 645073; 3 hits in 35 CRISPR screens.
DR   Pharos; P0CL82; Tbio.
DR   PRO; PR:P0CL82; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P0CL82; protein.
DR   ExpressionAtlas; P0CL82; baseline.
DR   Genevisible; P0CL82; HS.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; PTHR14047; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..117
FT                   /note="G antigen 12I"
FT                   /id="PRO_0000407493"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   117 AA;  12978 MW;  365ED8D41361C7AD CRC64;
     MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
     DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC