GG12J_HUMAN
ID GG12J_HUMAN Reviewed; 117 AA.
AC A6NER3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=G antigen 12J;
DE Short=GAGE-12J;
GN Name=GAGE12J;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP GAGE FAMILY.
RX PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA Gjerstorff M.F., Ditzel H.J.;
RT "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT newly identified members.";
RL Tissue Antigens 71:187-192(2008).
CC -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a
CC large variety of tumors whereas in normal tissues, expression is
CC restricted to germ cells. These genes organized in clustered repeats,
CC have a high degree of predicted sequence identity, but differ by
CC scattered single nucleotide substitution. Their sequences contain
CC either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized
CC by cytotoxic T-cells.
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC sequences, but the high identity of the GAGE members made impossible to
CC separate products of paralogous genes from polymorph products.
CC PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC identified genes and their products. {ECO:0000305}.
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DR EMBL; AF235097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43939.1; -.
DR AlphaFoldDB; A6NER3; -.
DR STRING; 9606.ENSP00000409832; -.
DR iPTMnet; A6NER3; -.
DR PhosphoSitePlus; A6NER3; -.
DR BioMuta; GAGE12J; -.
DR jPOST; A6NER3; -.
DR MassIVE; A6NER3; -.
DR MaxQB; A6NER3; -.
DR PaxDb; A6NER3; -.
DR PeptideAtlas; A6NER3; -.
DR PRIDE; A6NER3; -.
DR Antibodypedia; 61440; 28 antibodies from 5 providers.
DR Ensembl; ENST00000442437.3; ENSP00000409832.2; ENSG00000224659.3.
DR UCSC; uc033edf.2; human.
DR GeneCards; GAGE12J; -.
DR HGNC; HGNC:17778; GAGE12J.
DR HPA; ENSG00000224659; Tissue enriched (testis).
DR MIM; 300733; gene.
DR neXtProt; NX_A6NER3; -.
DR PharmGKB; PA162389200; -.
DR VEuPathDB; HostDB:ENSG00000224659; -.
DR eggNOG; ENOG502SZ68; Eukaryota.
DR HOGENOM; CLU_150116_0_0_1; -.
DR InParanoid; A6NER3; -.
DR PhylomeDB; A6NER3; -.
DR TreeFam; TF340669; -.
DR PathwayCommons; A6NER3; -.
DR SignaLink; A6NER3; -.
DR Pharos; A6NER3; Tdark.
DR PRO; PR:A6NER3; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A6NER3; protein.
DR Bgee; ENSG00000224659; Expressed in testis and 75 other tissues.
DR Genevisible; A6NER3; HS.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 1.
DR Pfam; PF05831; GAGE; 1.
DR SMART; SM01379; GAGE; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..117
FT /note="G antigen 12J"
FT /id="PRO_0000339405"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 9
FT /note="Y -> C (in dbSNP:rs7064096)"
FT /id="VAR_037385"
FT VARIANT 13
FT /note="R -> S (in dbSNP:rs7064105)"
FT /id="VAR_037386"
FT VARIANT 16
FT /note="P -> R (in dbSNP:rs6520418)"
FT /id="VAR_037387"
FT VARIANT 28
FT /note="R -> Q (in dbSNP:rs7064530)"
FT /id="VAR_043979"
SQ SEQUENCE 117 AA; 12896 MW; 44D4FFBB0596B2CE CRC64;
MSWRGRSTYY WPRPRPYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GKKQSQC
