GG6L1_HUMAN
ID GG6L1_HUMAN Reviewed; 668 AA.
AC Q8N7Z2; A0A087WU96;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Golgin subfamily A member 6-like protein 1;
GN Name=GOLGA6L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SIMILARITY: Belongs to the GOLGA6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK097517; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC116165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS73699.1; -.
DR RefSeq; NP_001001413.3; NM_001001413.3.
DR AlphaFoldDB; Q8N7Z2; -.
DR SMR; Q8N7Z2; -.
DR STRING; 9606.ENSP00000478478; -.
DR PhosphoSitePlus; Q8N7Z2; -.
DR BioMuta; GOLGA6L1; -.
DR DMDM; 300669642; -.
DR MassIVE; Q8N7Z2; -.
DR PeptideAtlas; Q8N7Z2; -.
DR PRIDE; Q8N7Z2; -.
DR Antibodypedia; 74192; 13 antibodies from 4 providers.
DR Ensembl; ENST00000611085.2; ENSP00000482864.1; ENSG00000278247.2.
DR Ensembl; ENST00000614055.2; ENSP00000478478.1; ENSG00000273976.2.
DR Ensembl; ENST00000616813.2; ENSP00000483916.1; ENSG00000275009.2.
DR GeneID; 283767; -.
DR KEGG; hsa:283767; -.
DR MANE-Select; ENST00000614055.2; ENSP00000478478.1; NM_001001413.3; NP_001001413.3.
DR UCSC; uc032bvr.2; human.
DR CTD; 283767; -.
DR GeneCards; GOLGA6L1; -.
DR HGNC; HGNC:37444; GOLGA6L1.
DR HPA; ENSG00000273976; Tissue enriched (testis).
DR neXtProt; NX_Q8N7Z2; -.
DR OpenTargets; ENSG00000273976; -.
DR VEuPathDB; HostDB:ENSG00000273976; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00940000163338; -.
DR InParanoid; Q8N7Z2; -.
DR OMA; QEENLWE; -.
DR OrthoDB; 358120at2759; -.
DR PhylomeDB; Q8N7Z2; -.
DR PathwayCommons; Q8N7Z2; -.
DR BioGRID-ORCS; 283767; 250 hits in 612 CRISPR screens.
DR ChiTaRS; GOLGA6L1; human.
DR GenomeRNAi; 283767; -.
DR Pharos; Q8N7Z2; Tdark.
DR PRO; PR:Q8N7Z2; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8N7Z2; protein.
DR Bgee; ENSG00000273976; Expressed in left testis and 17 other tissues.
DR InterPro; IPR026737; GOLGA6L.
DR PANTHER; PTHR23143; PTHR23143; 4.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..668
FT /note="Golgin subfamily A member 6-like protein 1"
FT /id="PRO_0000326027"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 177..663
FT /evidence="ECO:0000255"
FT COMPBIAS 9..44
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 491
FT /note="R -> W (in Ref. 1; AK097517)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 668 AA; 83069 MW; 6BEF9F37A46E1A6A CRC64;
MLMWPQPHLP THPHLPTHPH LPTHPHLPTH PHLPTHPHLP THPHLPTHPM MSKETRQSKL
AEAKEQLTDH HPQTNPSVGT AASDTKKKKI NNGTNPETTT SGGCHSPEDE QKASHQHQEA
LRRELEAQVH TIRILTCQKT ELQMALYYSQ HAVKQLEGEA RDLISRLHDS WKFAGELEQA
LSAVATQKKK ADRYIEELTK ERDALSLELY RNTITDEELK EKNAKLQEKL QLVESEKSEI
QLNVKELKRK LERAKLLLPQ QQLQAEADHL GKELQSVSAK LQAQVEENEL WNRLNQQQEE
KMWRQEEKIQ EWEEKIQEQE EKIREQEEKI REQEEKMRRQ EEMMWEKEEK MRRQEEMMWE
KEEKMRRLEE MMWEKEEKIR ELEEKMHEQE KIREQEEKRQ EEEKIREQEK RQEQEAKMWR
QEEKIREQEE KIREQEKKMW RQEEKIHEQE KIREEEKRQE QEEMWRQEEK IREQEEIWRQ
KEKMHEQEKI RKQEEKVWRQ EEKMHDQEEK IREQEEKMWR QEEKIREQEE KIREQEEKIR
EQEEMMQEQE EKMGEQEEKM QEQEKMRRQE EKIREQEEKI REQKEKIREQ EEKIWEQEEK
IREQEEMMQE QEEKMWEQEE KMCEQEEKMQ EQEEKMRRQE EKMWEQEVRL RQQEEKMQEH
QEHLEAAI
