GGACA_DANRE
ID GGACA_DANRE Reviewed; 161 AA.
AC A0JMM9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Gamma-glutamylaminecyclotransferase A;
DE Short=GGACT A;
DE EC=4.3.2.8 {ECO:0000250|UniProtKB:Q9BVM4};
DE AltName: Full=AIG2-like domain-containing protein 1-A;
DE AltName: Full=Gamma-glutamylamine cyclotransferase A;
DE AltName: Full=Gamma-glutamylamine cyclotransferase, tandem duplicate 1;
GN Name=ggact.1; ORFNames=zgc:154024;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May contribute to degradation of proteins cross-linked by
CC transglutaminases by degrading the cross-link between a lysine and a
CC glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from
CC L-gamma-glutamyl-L-epsilon-lysine. {ECO:0000250|UniProtKB:Q9BVM4}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-
CC lysine; Xref=Rhea:RHEA:16961, ChEBI:CHEBI:32551, ChEBI:CHEBI:58402,
CC ChEBI:CHEBI:133752; EC=4.3.2.8;
CC Evidence={ECO:0000250|UniProtKB:Q9BVM4};
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC {ECO:0000305}.
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DR EMBL; BC125938; AAI25939.1; -; mRNA.
DR RefSeq; NP_001071185.1; NM_001077717.1.
DR AlphaFoldDB; A0JMM9; -.
DR SMR; A0JMM9; -.
DR STRING; 7955.ENSDARP00000094571; -.
DR PaxDb; A0JMM9; -.
DR GeneID; 777609; -.
DR KEGG; dre:777609; -.
DR CTD; 777609; -.
DR ZFIN; ZDB-GENE-061103-94; ggact.1.
DR eggNOG; KOG4450; Eukaryota.
DR InParanoid; A0JMM9; -.
DR OrthoDB; 1389682at2759; -.
DR PhylomeDB; A0JMM9; -.
DR PRO; PR:A0JMM9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0061929; F:gamma-glutamylaminecyclotransferase activity; ISS:UniProtKB.
DR GO; GO:0042219; P:cellular modified amino acid catabolic process; ISS:UniProtKB.
DR CDD; cd06661; GGCT_like; 1.
DR InterPro; IPR009288; AIG2-like_dom.
DR InterPro; IPR039126; GGACT.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR PANTHER; PTHR12510; PTHR12510; 1.
DR Pfam; PF06094; GGACT; 1.
DR SUPFAM; SSF110857; SSF110857; 1.
PE 2: Evidence at transcript level;
KW Lyase; Reference proteome.
FT CHAIN 1..161
FT /note="Gamma-glutamylaminecyclotransferase A"
FT /id="PRO_0000320208"
FT ACT_SITE 101
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 26..29
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 161 AA; 18132 MW; 4AB54C5BE2F62A30 CRC64;
MIAIHILLLV FSNIVLPALC INVFVYGTLK KGQSNYHELT NTTHGQAEFI TCARTKDPYP
MVIATKDKFP FLLNVPGSGQ QVYGEIYNVD QNMLDFLDEF EECPDLYQRT SIQLKILKGN
GDSEEAFVYS TSTFDPDWLN KPTFSVYDAT GDPGNNCVSR E