GGACC_DANRE
ID GGACC_DANRE Reviewed; 152 AA.
AC A3KNL6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Gamma-glutamylaminecyclotransferase C;
DE Short=GGACT C;
DE EC=4.3.2.8 {ECO:0000250|UniProtKB:Q9BVM4};
DE AltName: Full=AIG2-like domain-containing protein 1-C;
DE AltName: Full=Gamma-glutamylamine cyclotransferase C;
DE AltName: Full=Gamma-glutamylamine cyclotransferase, tandem duplicate 3;
GN Name=ggact.3; ORFNames=zgc:162208;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May contribute to degradation of proteins cross-linked by
CC transglutaminases by degrading the cross-link between a lysine and a
CC glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from
CC L-gamma-glutamyl-L-epsilon-lysine. {ECO:0000250|UniProtKB:Q9BVM4}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-
CC lysine; Xref=Rhea:RHEA:16961, ChEBI:CHEBI:32551, ChEBI:CHEBI:58402,
CC ChEBI:CHEBI:133752; EC=4.3.2.8;
CC Evidence={ECO:0000250|UniProtKB:Q9BVM4};
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC {ECO:0000305}.
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DR EMBL; BC133906; AAI33907.1; -; mRNA.
DR RefSeq; NP_001083029.1; NM_001089560.1.
DR AlphaFoldDB; A3KNL6; -.
DR SMR; A3KNL6; -.
DR STRING; 7955.ENSDARP00000094561; -.
DR PaxDb; A3KNL6; -.
DR PeptideAtlas; A3KNL6; -.
DR PRIDE; A3KNL6; -.
DR Ensembl; ENSDART00000103785; ENSDARP00000094561; ENSDARG00000070579.
DR Ensembl; ENSDART00000152555; ENSDARP00000126618; ENSDARG00000070579.
DR Ensembl; ENSDART00000190207; ENSDARP00000157475; ENSDARG00000070579.
DR GeneID; 100038780; -.
DR KEGG; dre:100038780; -.
DR CTD; 100038780; -.
DR ZFIN; ZDB-GENE-070424-26; ggact.3.
DR eggNOG; KOG4450; Eukaryota.
DR GeneTree; ENSGT00390000010543; -.
DR HOGENOM; CLU_083466_1_0_1; -.
DR InParanoid; A3KNL6; -.
DR OMA; NEKLECW; -.
DR OrthoDB; 1389682at2759; -.
DR PhylomeDB; A3KNL6; -.
DR TreeFam; TF323258; -.
DR PRO; PR:A3KNL6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 1.
DR Bgee; ENSDARG00000070579; Expressed in granulocyte and 17 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0061929; F:gamma-glutamylaminecyclotransferase activity; ISS:UniProtKB.
DR GO; GO:0042219; P:cellular modified amino acid catabolic process; ISS:UniProtKB.
DR CDD; cd06661; GGCT_like; 1.
DR InterPro; IPR009288; AIG2-like_dom.
DR InterPro; IPR039126; GGACT.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR PANTHER; PTHR12510; PTHR12510; 1.
DR Pfam; PF06094; GGACT; 1.
DR SUPFAM; SSF110857; SSF110857; 1.
PE 2: Evidence at transcript level;
KW Lyase; Reference proteome.
FT CHAIN 1..152
FT /note="Gamma-glutamylaminecyclotransferase C"
FT /id="PRO_0000320207"
FT ACT_SITE 84
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 9..12
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 152 AA; 17443 MW; 153B020D0E6A111C CRC64;
MSTHHVFVYG SLKKGQPNHH ELLNSNNGQA EFITCAQTKE PYPLVIATKH NIPFLLNVPG
SGKQVSGEIY SVDQKMLEFL DWFEKCPDWY QRTSIQLEIL KGNGESGRIE EASVYSKINF
EPDWLNKPTH ESYDTNGDHG LKFVCREDRK DD