GGACT_RAT
ID GGACT_RAT Reviewed; 149 AA.
AC Q4KM86;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Gamma-glutamylaminecyclotransferase;
DE Short=GGACT;
DE EC=4.3.2.8 {ECO:0000250|UniProtKB:Q9BVM4};
DE AltName: Full=AIG2-like domain-containing protein 1;
DE AltName: Full=Gamma-glutamylamine cyclotransferase;
GN Name=Ggact; Synonyms=A2ld1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Contributes to degradation of proteins cross-linked by
CC transglutaminases by degrading the cross-link between a lysine and a
CC glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from
CC L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-
CC alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine
CC and L-gamma-glutamyl-L-alpha-alanine. {ECO:0000250|UniProtKB:Q9BVM4}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-
CC lysine; Xref=Rhea:RHEA:16961, ChEBI:CHEBI:32551, ChEBI:CHEBI:58402,
CC ChEBI:CHEBI:133752; EC=4.3.2.8;
CC Evidence={ECO:0000250|UniProtKB:Q9BVM4};
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q9BVM4}.
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC {ECO:0000305}.
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DR EMBL; BC098699; AAH98699.1; -; mRNA.
DR AlphaFoldDB; Q4KM86; -.
DR SMR; Q4KM86; -.
DR STRING; 10116.ENSRNOP00000000118; -.
DR jPOST; Q4KM86; -.
DR PaxDb; Q4KM86; -.
DR Ensembl; ENSRNOT00000119176; ENSRNOP00000092826; ENSRNOG00000027040.
DR RGD; 1304748; Ggact.
DR eggNOG; KOG4450; Eukaryota.
DR GeneTree; ENSGT00390000010543; -.
DR HOGENOM; CLU_083466_1_0_1; -.
DR InParanoid; Q4KM86; -.
DR OMA; YQRTALR; -.
DR PhylomeDB; Q4KM86; -.
DR TreeFam; TF323258; -.
DR BioCyc; MetaCyc:MON-10043; -.
DR PRO; PR:Q4KM86; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000027040; Expressed in kidney and 19 other tissues.
DR Genevisible; Q4KM86; RN.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0061929; F:gamma-glutamylaminecyclotransferase activity; ISS:UniProtKB.
DR GO; GO:0042219; P:cellular modified amino acid catabolic process; ISS:UniProtKB.
DR CDD; cd06661; GGCT_like; 1.
DR InterPro; IPR009288; AIG2-like_dom.
DR InterPro; IPR039126; GGACT.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR PANTHER; PTHR12510; PTHR12510; 1.
DR Pfam; PF06094; GGACT; 1.
DR SUPFAM; SSF110857; SSF110857; 1.
PE 2: Evidence at transcript level;
KW Lyase; Reference proteome.
FT CHAIN 1..149
FT /note="Gamma-glutamylaminecyclotransferase"
FT /id="PRO_0000320205"
FT ACT_SITE 82
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 7..10
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 149 AA; 16925 MW; 6E68E8CFDA42F77D CRC64;
MAHIFVYGTL KRGQPNHKVM LDQSHGLATF RGRGCTVESF PLVIAGEHNI PWLLHLPGKG
HCVAGEIYEV DEQMLRFLDD FEGCPSMYQR TALQVRVLEW EGAGGPGDSV QCFVYSTATY
APEWLFLPYH KNYDSEGPHG LRYNPRENR
