ID   GGACT_XENLA             Reviewed;         138 AA.
AC   Q66KX0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Gamma-glutamylaminecyclotransferase;
DE            Short=GGACT;
DE            EC=4.3.2.8 {ECO:0000250|UniProtKB:Q9BVM4};
DE   AltName: Full=AIG2-like domain-containing protein 1;
DE   AltName: Full=Gamma-glutamylamine cyclotransferase;
GN   Name=ggact; Synonyms=a2ld1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May contribute to degradation of proteins cross-linked by
CC       transglutaminases by degrading the cross-link between a lysine and a
CC       glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from
CC       L-gamma-glutamyl-L-epsilon-lysine. {ECO:0000250|UniProtKB:Q9BVM4}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-
CC         lysine; Xref=Rhea:RHEA:16961, ChEBI:CHEBI:32551, ChEBI:CHEBI:58402,
CC         ChEBI:CHEBI:133752; EC=4.3.2.8;
CC         Evidence={ECO:0000250|UniProtKB:Q9BVM4};
CC   -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC       {ECO:0000305}.
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DR   EMBL; BC078529; AAH78529.1; -; mRNA.
DR   RefSeq; NP_001087302.1; NM_001093833.1.
DR   AlphaFoldDB; Q66KX0; -.
DR   SMR; Q66KX0; -.
DR   DNASU; 447124; -.
DR   GeneID; 447124; -.
DR   KEGG; xla:447124; -.
DR   CTD; 447124; -.
DR   Xenbase; XB-GENE-961430; ggact.L.
DR   OrthoDB; 1389682at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 447124; Expressed in kidney and 14 other tissues.
DR   GO; GO:0061929; F:gamma-glutamylaminecyclotransferase activity; ISS:UniProtKB.
DR   GO; GO:0042219; P:cellular modified amino acid catabolic process; ISS:UniProtKB.
DR   CDD; cd06661; GGCT_like; 1.
DR   InterPro; IPR009288; AIG2-like_dom.
DR   InterPro; IPR039126; GGACT.
DR   InterPro; IPR013024; GGCT-like.
DR   InterPro; IPR036568; GGCT-like_sf.
DR   PANTHER; PTHR12510; PTHR12510; 1.
DR   Pfam; PF06094; GGACT; 1.
DR   SUPFAM; SSF110857; SSF110857; 1.
PE   2: Evidence at transcript level;
KW   Lyase; Reference proteome.
FT   CHAIN           1..138
FT                   /note="Gamma-glutamylaminecyclotransferase"
FT                   /id="PRO_0000320209"
FT   ACT_SITE        63
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   138 AA;  16062 MW;  60695C2981F6744F CRC64;
     MTCYKHGKAV FKGMGKTVEK YPLVIAEEAN IPFLLNIPGT GRRIIGEIYS VDEQLLHFLD
     DFEGCPNWYQ RTPQEIEILE WEGTDDSPDE RPAANSIITC FVYSTTCYQP EWLQLPYHKC
     YDAFGNHGLR YIRHRDII