GGCT_BOVIN
ID GGCT_BOVIN Reviewed; 188 AA.
AC Q32LE4;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Gamma-glutamylcyclotransferase;
DE EC=4.3.2.9 {ECO:0000250|UniProtKB:O75223};
GN Name=GGCT;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the formation of 5-oxoproline from gamma-glutamyl
CC dipeptides and may play a significant role in glutathione homeostasis.
CC Induces release of cytochrome c from mitochondria with resultant
CC induction of apoptosis. {ECO:0000250|UniProtKB:O75223}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline +
CC an L-alpha-amino acid; Xref=Rhea:RHEA:20505, ChEBI:CHEBI:58402,
CC ChEBI:CHEBI:59869, ChEBI:CHEBI:71304; EC=4.3.2.9;
CC Evidence={ECO:0000250|UniProtKB:O75223};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20506;
CC Evidence={ECO:0000250|UniProtKB:O75223};
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:O75223}.
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC {ECO:0000305}.
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DR EMBL; BC109622; AAI09623.1; -; mRNA.
DR RefSeq; NP_001032699.1; NM_001037610.2.
DR AlphaFoldDB; Q32LE4; -.
DR SMR; Q32LE4; -.
DR STRING; 9913.ENSBTAP00000014010; -.
DR PaxDb; Q32LE4; -.
DR PRIDE; Q32LE4; -.
DR Ensembl; ENSBTAT00000014010; ENSBTAP00000014010; ENSBTAG00000010597.
DR GeneID; 533374; -.
DR KEGG; bta:533374; -.
DR CTD; 79017; -.
DR VEuPathDB; HostDB:ENSBTAG00000010597; -.
DR VGNC; VGNC:107225; GGCT.
DR eggNOG; KOG4059; Eukaryota.
DR GeneTree; ENSGT00500000044921; -.
DR HOGENOM; CLU_048475_2_1_1; -.
DR InParanoid; Q32LE4; -.
DR OMA; APHDYVM; -.
DR OrthoDB; 1484710at2759; -.
DR TreeFam; TF314378; -.
DR Reactome; R-BTA-174403; Glutathione synthesis and recycling.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000010597; Expressed in oocyte and 103 other tissues.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0003839; F:gamma-glutamylcyclotransferase activity; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0001836; P:release of cytochrome c from mitochondria; ISS:UniProtKB.
DR CDD; cd06661; GGCT_like; 1.
DR InterPro; IPR017939; G-Glutamylcylcotransferase.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR PANTHER; PTHR12935; PTHR12935; 1.
DR SUPFAM; SSF110857; SSF110857; 1.
PE 2: Evidence at transcript level;
KW Lyase; Phosphoprotein; Reference proteome.
FT CHAIN 1..188
FT /note="Gamma-glutamylcyclotransferase"
FT /id="PRO_0000250163"
FT ACT_SITE 98
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:O75223"
FT BINDING 19..22
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:O75223"
FT MOD_RES 173
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D7X8"
SQ SEQUENCE 188 AA; 21177 MW; 96DAE7FD5C8423F8 CRC64;
MANFGCEDLR SQDGESFLYF AYGSNLLTER IHLRNPSAVF YSVARLQDFK LDFGNPQGKT
SETWHGGIAT IFESPGDEVW GVVWKMNKSN LSSLDKQEGV KSGMYVPIEV TVSTQEGKEI
TCRSYQMTNY ESVPPSPQYK KVICMGAKEN GLPLEYQKKL NSIEPNDYKG KVSEEIEDII
KKGEAKTH
