GGE2D_HUMAN
ID GGE2D_HUMAN Reviewed; 116 AA.
AC Q9UEU5; A6NG46; A6NNR8; B7ZL76; Q4V325;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=G antigen 2D;
DE Short=GAGE-2D;
DE AltName: Full=Cancer/testis antigen 4.8;
DE Short=CT4.8;
DE AltName: Full=G antigen 8;
DE Short=GAGE-8;
GN Name=GAGE2D;
GN and
GN Name=GAGE8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10397259;
RA De Backer O., Arden K.C., Boretti M., Vantomme V., De Smet C., Czekay S.,
RA Viars C.S., De Plaen E., Brasseur F., Chomez P., Van den Eynde B., Boon T.,
RA van der Bruggen P.;
RT "Characterization of the GAGE genes that are expressed in various human
RT cancers and in normal testis.";
RL Cancer Res. 59:3157-3165(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lung, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GAGE FAMILY.
RX PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x;
RA Gjerstorff M.F., Ditzel H.J.;
RT "An overview of the GAGE cancer/testis antigen family with the inclusion of
RT newly identified members.";
RL Tissue Antigens 71:187-192(2008).
CC -!- INTERACTION:
CC Q9UEU5; Q53SE7: FLJ13057; NbExp=5; IntAct=EBI-751641, EBI-10172181;
CC Q9UEU5; Q8NEA9: GMCL2; NbExp=5; IntAct=EBI-751641, EBI-745707;
CC -!- TISSUE SPECIFICITY: Not expressed in normal tissues, except in testis,
CC but expressed by a large proportion of tumors of various histological
CC origins.
CC -!- MISCELLANEOUS: This gene belongs to a family of genes organized in
CC clustered repeats. They have a high degree of predicted sequence
CC identity, but differ by scattered single nucleotide substitution. Their
CC sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY
CC which is recognized by cytotoxic T-cells.
CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
CC -!- CAUTION: The first GAGE nomenclature was based on identified mRNA
CC sequences, but the high identity of the GAGE members made impossible to
CC separate products of paralogous genes from polymorph products.
CC PubMed:18179644 presented a new GAGE gene nomenclature based on the
CC identified genes and their products. {ECO:0000305}.
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DR EMBL; AF055473; AAC33676.1; -; mRNA.
DR EMBL; BX649339; CAI95422.1; -; Genomic_DNA.
DR EMBL; BC018052; AAH18052.1; -; mRNA.
DR EMBL; BC143620; AAI43621.1; -; mRNA.
DR RefSeq; NP_001091877.1; NM_001098407.1.
DR RefSeq; NP_001120672.2; NM_001127200.2.
DR RefSeq; NP_036328.1; NM_012196.1.
DR AlphaFoldDB; Q9UEU5; -.
DR BioGRID; 609809; 2.
DR BioGRID; 755858; 8.
DR IntAct; Q9UEU5; 2.
DR iPTMnet; Q9UEU5; -.
DR PhosphoSitePlus; Q9UEU5; -.
DR BioMuta; HGNC:31959; -.
DR DMDM; 21759147; -.
DR jPOST; Q9UEU5; -.
DR MassIVE; Q9UEU5; -.
DR MaxQB; Q9UEU5; -.
DR PaxDb; Q9UEU5; -.
DR PeptideAtlas; Q9UEU5; -.
DR PRIDE; Q9UEU5; -.
DR TopDownProteomics; Q9UEU5; -.
DR DNASU; 26749; -.
DR GeneID; 100101629; -.
DR GeneID; 26749; -.
DR GeneID; 729408; -.
DR KEGG; hsa:100101629; -.
DR KEGG; hsa:26749; -.
DR KEGG; hsa:729408; -.
DR CTD; 100101629; -.
DR CTD; 26749; -.
DR CTD; 729408; -.
DR GeneCards; GAGE2D; -.
DR GeneCards; GAGE8; -.
DR HGNC; HGNC:31959; GAGE2D.
DR HGNC; HGNC:4106; GAGE8.
DR MIM; 300638; gene.
DR MIM; 300735; gene.
DR neXtProt; NX_Q9UEU5; -.
DR PharmGKB; PA162389275; -.
DR InParanoid; Q9UEU5; -.
DR PhylomeDB; Q9UEU5; -.
DR TreeFam; TF340669; -.
DR PathwayCommons; Q9UEU5; -.
DR SignaLink; Q9UEU5; -.
DR BioGRID-ORCS; 100101629; 0 hits in 16 CRISPR screens.
DR BioGRID-ORCS; 26749; 1 hit in 28 CRISPR screens.
DR BioGRID-ORCS; 729408; 2 hits in 110 CRISPR screens.
DR Pharos; Q9UEU5; Tdark.
DR PRO; PR:Q9UEU5; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9UEU5; protein.
DR InterPro; IPR031320; GAGE.
DR InterPro; IPR008625; GAGE_fam.
DR PANTHER; PTHR14047; PTHR14047; 1.
DR Pfam; PF05831; GAGE; 1.
DR SMART; SM01379; GAGE; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..116
FT /note="G antigen 2D"
FT /id="PRO_0000148346"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 116 AA; 12764 MW; DD3052939E66F19A CRC64;
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED
EGASAGQGPK PEADSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQC
