ID   GGN2_GLARU              Reviewed;          33 AA.
AC   P80396;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Gaegurin-2;
GN   Name=GGN2;
OS   Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Glandirana.
OX   NCBI_TaxID=8410;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=7999137; DOI=10.1006/bbrc.1994.2757;
RA   Park J.M., Jung J.-E., Lee B.J.;
RT   "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa.";
RL   Biochem. Biophys. Res. Commun. 205:948-954(1994).
CC   -!- FUNCTION: Has a non-hemolytic activity. Has a broad spectrum of
CC       activity against both Gram-positive and Gram-negative bacteria, fungi
CC       and protozoa.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   PIR; PC2301; PC2301.
DR   AlphaFoldDB; P80396; -.
DR   SMR; P80396; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Gaegurin-2"
FT                   /id="PRO_0000044653"
FT   DISULFID        27..33
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   33 AA;  3322 MW;  C1EA65E2488E8E15 CRC64;
     GIMSIVKDVA KNAAKEAAKG ALSTLSCKLA KTC