GGN3_GLARU
ID GGN3_GLARU Reviewed; 33 AA.
AC P80397;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Gaegurin-3;
GN Name=GGN3;
OS Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Glandirana.
OX NCBI_TaxID=8410;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Skin secretion;
RX PubMed=7999137; DOI=10.1006/bbrc.1994.2757;
RA Park J.M., Jung J.-E., Lee B.J.;
RT "Antimicrobial peptides from the skin of a Korean frog, Rana rugosa.";
RL Biochem. Biophys. Res. Commun. 205:948-954(1994).
CC -!- FUNCTION: Has a non-hemolytic activity. Has a broad spectrum of
CC activity against both Gram-positive and Gram-negative bacteria, fungi
CC and protozoa.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000305}.
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DR PIR; PC2302; PC2302.
DR AlphaFoldDB; P80397; -.
DR SMR; P80397; -.
DR PRIDE; P80397; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR012521; Antimicrobial_frog_2.
DR Pfam; PF08023; Antimicrobial_2; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Secreted.
FT PEPTIDE 1..33
FT /note="Gaegurin-3"
FT /id="PRO_0000044654"
FT DISULFID 27..33
FT /evidence="ECO:0000250"
SQ SEQUENCE 33 AA; 3309 MW; C1EA65E2489E5475 CRC64;
GIMSIVKDVA KTAAKEAAKG ALSTLSCKLA KTC