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GGNB1_MOUSE
ID   GGNB1_MOUSE             Reviewed;         370 AA.
AC   Q6K1E7; B9WZ58; Q8C5T9;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Gametogenetin-binding protein 1;
GN   Name=Ggnbp1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=C57BL/6J;
RX   PubMed=15625700; DOI=10.1002/mrd.20214;
RA   Zhou Y., Zhao Q., Bishop C.E., Huang P., Lu B.;
RT   "Identification and characterization of a novel testicular germ cell-
RT   specific gene Ggnbp1.";
RL   Mol. Reprod. Dev. 70:301-307(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=19208545; DOI=10.1095/biolreprod.108.074013;
RA   Aihara T., Nakamura N., Honda S., Hirose S.;
RT   "A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in
RT   mitochondrial morphogenesis during spermatogenesis in mice.";
RL   Biol. Reprod. 80:762-770(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INTERACTION WITH GGN, AND SUBCELLULAR LOCATION.
RX   PubMed=15642376; DOI=10.1016/j.febslet.2004.10.112;
RA   Zhang J., Wang Y., Zhou Y., Cao Z., Huang P., Lu B.;
RT   "Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential
RT   interaction partners of testicular germ cell-specific protein GGN1.";
RL   FEBS Lett. 579:559-566(2005).
RN   [7]
RP   INTERACTION WITH GGN.
RX   PubMed=15892049; DOI=10.1002/mrd.20313;
RA   Zhao Q., Zhou Y., Cao Z., Zhu H., Huang P., Lu B.;
RT   "Germ-cell specific protein gametogenetin protein 2 (GGN2), expression in
RT   the testis, and association with intracellular membrane.";
RL   Mol. Reprod. Dev. 72:31-39(2005).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Induces mitochondrial fragmentation, possibly by promoting
CC       DNM1L-dependent fission and may play a role in mitochondrial
CC       morphogenesis during spermatogenesis. {ECO:0000269|PubMed:19208545}.
CC   -!- SUBUNIT: Interacts with isoform 1 and isoform 2 of GGN.
CC       {ECO:0000269|PubMed:15642376, ECO:0000269|PubMed:15892049}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein.
CC       Golgi apparatus. Mitochondrion intermembrane space.
CC   -!- TISSUE SPECIFICITY: Testis-specific. In the testis, expressed only in
CC       germ cells and not in somatic cells. Expression starts in late primary
CC       spermatocytes in stage X-XII tubules and gradually increases towards
CC       step 1-3 spermatids in stage I-III tubules. Expression then declines
CC       continuously and disappears after step 7 spermatids in stage VII
CC       tubules (at protein level). {ECO:0000269|PubMed:19208545}.
CC   -!- DEVELOPMENTAL STAGE: Specifically expressed in germ cells tightly
CC       related to meiosis. In the developing mouse testis, it is not detected
CC       in the testes of 14-day-old mice, when pachytene spermatocytes are
CC       still in their early stage, while it is detected in tubules with late
CC       pachytene spermatocytes and spermatids in the testes of 21-day-old
CC       mice. {ECO:0000269|PubMed:15625700}.
CC   -!- DOMAIN: The N-terminal domain is required for targeting to the
CC       mitochondrion.
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DR   EMBL; AY141192; AAN10253.1; -; mRNA.
DR   EMBL; AB250379; BAH22703.1; -; mRNA.
DR   EMBL; AK077129; BAC36632.1; -; mRNA.
DR   EMBL; CH466606; EDL22529.1; -; Genomic_DNA.
DR   EMBL; BC049764; AAH49764.1; -; mRNA.
DR   CCDS; CCDS28559.1; -.
DR   RefSeq; NP_081820.2; NM_027544.2.
DR   AlphaFoldDB; Q6K1E7; -.
DR   SMR; Q6K1E7; -.
DR   BioGRID; 214246; 1.
DR   IntAct; Q6K1E7; 2.
DR   MINT; Q6K1E7; -.
DR   STRING; 10090.ENSMUSP00000051800; -.
DR   iPTMnet; Q6K1E7; -.
DR   PhosphoSitePlus; Q6K1E7; -.
DR   PaxDb; Q6K1E7; -.
DR   PRIDE; Q6K1E7; -.
DR   ProteomicsDB; 268874; -.
DR   Ensembl; ENSMUST00000053683; ENSMUSP00000051800; ENSMUSG00000048731.
DR   GeneID; 70772; -.
DR   KEGG; mmu:70772; -.
DR   UCSC; uc008bfh.2; mouse.
DR   CTD; 449520; -.
DR   MGI; MGI:3055306; Ggnbp1.
DR   VEuPathDB; HostDB:ENSMUSG00000048731; -.
DR   eggNOG; KOG1870; Eukaryota.
DR   GeneTree; ENSGT00390000006663; -.
DR   HOGENOM; CLU_816260_0_0_1; -.
DR   InParanoid; Q6K1E7; -.
DR   OMA; SMFRFFR; -.
DR   OrthoDB; 1356995at2759; -.
DR   PhylomeDB; Q6K1E7; -.
DR   TreeFam; TF339395; -.
DR   BioGRID-ORCS; 70772; 2 hits in 69 CRISPR screens.
DR   ChiTaRS; Ggnbp1; mouse.
DR   PRO; PR:Q6K1E7; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q6K1E7; protein.
DR   Bgee; ENSMUSG00000048731; Expressed in spermatocyte and 102 other tissues.
DR   ExpressionAtlas; Q6K1E7; baseline and differential.
DR   Genevisible; Q6K1E7; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR026670; GGNBP1.
DR   InterPro; IPR028135; Ub_USP-typ.
DR   PANTHER; PTHR21646:SF2; PTHR21646:SF2; 1.
DR   Pfam; PF14836; Ubiquitin_3; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Differentiation; Golgi apparatus;
KW   Membrane; Mitochondrion; Reference proteome; Spermatogenesis.
FT   CHAIN           1..370
FT                   /note="Gametogenetin-binding protein 1"
FT                   /id="PRO_0000239346"
FT   REGION          26..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..370
FT                   /note="Required for induction of mitochondrial
FT                   fragmentation"
FT   REGION          240..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..370
FT                   /note="Interaction with GGN"
FT   COMPBIAS        28..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..263
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        207..209
FT                   /note="LKP -> SKR (in Ref. 1; AAN10253)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        241
FT                   /note="A -> V (in Ref. 1; AAN10253)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   370 AA;  40505 MW;  2B7E1C6CF4F83ED0 CRC64;
     MAAPARTPRS RILGCSSMLR FLRNLVGSKG GSKSTNKPLT RSQPSSSWEQ DVVSPMMGHQ
     GGRGRKEPRA KVHSAASSNG KREPPPRVLS AAPSNPRHDA FELGTGDSGS QTLTSKDVPK
     LRAQGVEVTS VPLRGTWEVL EQLPEKKGEE EEPVGEVSGA SDREHFGQAL ETEQGCLQWV
     PGPLALTPGA FIKEEEDEHC PIEFGDLKPS SCKVGSTPWN YLLGLYKQLQ KSAMAKAQRP
     AAPQLALKDG LPHEEKGERE EAVDESCPKW CAPRASSDES CPKWCAPRAS TYQSPLQKKF
     RSTDTVGFVE SELKKILSVQ REARLWKVGN PEGRELLTQP DITLEEAGMV DGQHLLLEEM
     DEMGNWPPPD
 
 
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