ID   GGNB1_RAT               Reviewed;         373 AA.
AC   Q5J2D6;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Gametogenetin-binding protein 1;
GN   Name=Ggnbp1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=15625700; DOI=10.1002/mrd.20214;
RA   Zhou Y., Zhao Q., Bishop C.E., Huang P., Lu B.;
RT   "Identification and characterization of a novel testicular germ cell-
RT   specific gene Ggnbp1.";
RL   Mol. Reprod. Dev. 70:301-307(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Induces mitochondrial fragmentation, possibly by promoting
CC       DNM1L-dependent fission and may play a role in mitochondrial
CC       morphogenesis during spermatogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GGN. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Golgi apparatus
CC       {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}.
CC   -!- DOMAIN: The N-terminal domain is required for targeting to the
CC       mitochondrion. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY529104; AAS93935.1; -; mRNA.
DR   EMBL; BC105838; AAI05839.1; -; mRNA.
DR   RefSeq; NP_001009972.1; NM_001009972.1.
DR   AlphaFoldDB; Q5J2D6; -.
DR   SMR; Q5J2D6; -.
DR   STRING; 10116.ENSRNOP00000000577; -.
DR   PaxDb; Q5J2D6; -.
DR   Ensembl; ENSRNOT00000000577; ENSRNOP00000000577; ENSRNOG00000000486.
DR   GeneID; 494520; -.
DR   KEGG; rno:494520; -.
DR   UCSC; RGD:1359729; rat.
DR   CTD; 449520; -.
DR   RGD; 1359729; Ggnbp1.
DR   eggNOG; KOG1870; Eukaryota.
DR   GeneTree; ENSGT00390000006663; -.
DR   HOGENOM; CLU_816260_0_0_1; -.
DR   InParanoid; Q5J2D6; -.
DR   OMA; SMFRFFR; -.
DR   OrthoDB; 1356995at2759; -.
DR   PhylomeDB; Q5J2D6; -.
DR   TreeFam; TF339395; -.
DR   PRO; PR:Q5J2D6; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000486; Expressed in testis and 14 other tissues.
DR   Genevisible; Q5J2D6; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR026670; GGNBP1.
DR   InterPro; IPR028135; Ub_USP-typ.
DR   PANTHER; PTHR21646:SF2; PTHR21646:SF2; 1.
DR   Pfam; PF14836; Ubiquitin_3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; Golgi apparatus;
KW   Membrane; Mitochondrion; Reference proteome; Spermatogenesis.
FT   CHAIN           1..373
FT                   /note="Gametogenetin-binding protein 1"
FT                   /id="PRO_0000239347"
FT   REGION          26..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..373
FT                   /note="Required for induction of mitochondrial
FT                   fragmentation"
FT                   /evidence="ECO:0000250"
FT   REGION          237..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..373
FT                   /note="Interaction with GGN"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        27..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..268
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  40854 MW;  3DCB8BD316FB328A CRC64;
     MAAQARTPRS RILGCSSMLR FLRSLVGSKG SSKSSNRPLN RSQPSSSPEQ DVVSPTMGHQ
     GGCGRKETRP RVLSATSSNG KREPRPRVLS AAPSNQRLRD ASGLGTGDTG SQTLTSKDVL
     KLRAQGVEVT SVPTRGTWEV LEHLPEKKGE EGEPAGEVSG ASDRAHFGQA LEAEQGCLQW
     VSGPMVLPPE AFIKEEEDEH CLIDFGDLRL SSCKVGSTPW NYLLGLYKQL QKSAMTKAQR
     PDADAPQFAL KDSSPTEERG EREEAVDESS LKWCAPRASS DDSNLKWCAP RNSTYQSPLQ
     KTFRSTDTVG FVESELKKIL AVQREARLWK VGNPEGRELL TQPDITLEEA GMVDGQHLLL
     EEMDEMGNWP PPE