ID   GGNB2_CHICK             Reviewed;         698 AA.
AC   Q6GVH4; Q5ZJV2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Gametogenetin-binding protein 2;
DE   AltName: Full=Protein ZNF403;
GN   Name=GGNBP2; Synonyms=ZNF403; ORFNames=RCJMB04_15h5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642376; DOI=10.1016/j.febslet.2004.10.112;
RA   Zhang J., Wang Y., Zhou Y., Cao Z., Huang P., Lu B.;
RT   "Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential
RT   interaction partners of testicular germ cell-specific protein GGN1.";
RL   FEBS Lett. 579:559-566(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May be involved in spermatogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6GVH4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6GVH4-2; Sequence=VSP_019181;
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DR   EMBL; AJ720332; CAG31991.1; -; mRNA.
DR   EMBL; AY633743; AAT47122.1; -; mRNA.
DR   RefSeq; NP_001001899.1; NM_001001899.1. [Q6GVH4-1]
DR   RefSeq; XP_015151295.1; XM_015295809.1. [Q6GVH4-2]
DR   AlphaFoldDB; Q6GVH4; -.
DR   SMR; Q6GVH4; -.
DR   STRING; 9031.ENSGALP00000008651; -.
DR   PaxDb; Q6GVH4; -.
DR   Ensembl; ENSGALT00000008665; ENSGALP00000008651; ENSGALG00000005397. [Q6GVH4-1]
DR   GeneID; 425053; -.
DR   KEGG; gga:425053; -.
DR   CTD; 79893; -.
DR   VEuPathDB; HostDB:geneid_425053; -.
DR   eggNOG; ENOG502QQ20; Eukaryota.
DR   GeneTree; ENSGT00390000009552; -.
DR   HOGENOM; CLU_024870_0_0_1; -.
DR   InParanoid; Q6GVH4; -.
DR   OMA; SEEKGYC; -.
DR   OrthoDB; 398180at2759; -.
DR   PhylomeDB; Q6GVH4; -.
DR   PRO; PR:Q6GVH4; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000005397; Expressed in testis and 13 other tissues.
DR   ExpressionAtlas; Q6GVH4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR026073; GGNBP2.
DR   PANTHER; PTHR13601; PTHR13601; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..698
FT                   /note="Gametogenetin-binding protein 2"
FT                   /id="PRO_0000239351"
FT   REGION          555..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         282
FT                   /note="G -> GYE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15642098"
FT                   /id="VSP_019181"
FT   CONFLICT        104
FT                   /note="V -> I (in Ref. 2; AAT47122)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        123
FT                   /note="S -> P (in Ref. 2; AAT47122)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   698 AA;  79222 MW;  B1EE2C32DCCB39BF CRC64;
     MARLVAVCRD GEEEFPFEKR QIPLYIDDTL TMVMEFPDNV LNLDGHQNNG AQLKQFIQRH
     SMLKQQDLNI AMMVTSREVL SALSQLVPCV GCRRSVERLF SQLVESGNPA LEPLAVGPKG
     VLSVTRSCMT DAKKLYTLFY VHGSKLNDMI DAIPKSKKNK RCQLHSLDTH KPKPLGGCWM
     DVWELMSQEC RDEVVLIDSS CLLETLETYL RKHRFCTDCK NKVLRAYNIL IGELDCSKEK
     GYCAALYEGL RCCPHERHIH VCCETDFIAH LLGRAEPEFA GGRRERHAKT IDIAQEEVLT
     CLGIHLYERL HRIWQKLRAE EQTWQMLFYL GVDALRKSFE MAVEKVQGIS RLEQLCEEFS
     EEERVRELKQ EKKRQKRKNR RKNKCVCEIP TPLQAAEEKE INQAKENLDF TENSCKACGS
     TEEANNCVEV IVTNESTSCT CPSSGTLLGS PKIKKGLSPH CNGSDCGYSS SMEGSETGSR
     EGSDVACTEG ICNHDENGDD SCVHRCDDKE EDGDSCVECW ANSEESNTKG KNKKKKKKSK
     TLKCENEHIQ KLGSCMADPG NRETSGNTTH TEFHRDKTKD THAESCCSSE KSGQQLPWFE
     HMKNVSQFAE PTEMSLVPDT GKGAKSLVEL LDESECTSDE EIFISQDEIQ SFMANNKSFY
     SNREQYRQHL KEKFNKYCRL NDHKRPICNG WLTTAGAN