GGNB2_DROME
ID GGNB2_DROME Reviewed; 671 AA.
AC Q9VNG1; Q8IPP6; Q8MR07;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 3.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Gametogenetin-binding protein 2-like;
GN ORFNames=CG2182;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q9VNG1-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q9VNG1-2; Sequence=VSP_019182;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM52714.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF51975.3; -; Genomic_DNA.
DR EMBL; AE014297; AAN13256.1; -; Genomic_DNA.
DR EMBL; AY122202; AAM52714.1; ALT_FRAME; mRNA.
DR EMBL; BT016040; AAV36925.1; -; mRNA.
DR RefSeq; NP_649570.1; NM_141313.3. [Q9VNG1-1]
DR AlphaFoldDB; Q9VNG1; -.
DR SMR; Q9VNG1; -.
DR BioGRID; 65903; 4.
DR STRING; 7227.FBpp0078379; -.
DR PaxDb; Q9VNG1; -.
DR DNASU; 40697; -.
DR EnsemblMetazoa; FBtr0078730; FBpp0078379; FBgn0037360. [Q9VNG1-1]
DR GeneID; 40697; -.
DR KEGG; dme:Dmel_CG2182; -.
DR UCSC; CG2182-RA; d. melanogaster. [Q9VNG1-1]
DR FlyBase; FBgn0037360; CG2182.
DR VEuPathDB; VectorBase:FBgn0037360; -.
DR eggNOG; ENOG502QQ20; Eukaryota.
DR GeneTree; ENSGT00390000009552; -.
DR HOGENOM; CLU_024870_0_0_1; -.
DR InParanoid; Q9VNG1; -.
DR OMA; MMLMDLN; -.
DR PhylomeDB; Q9VNG1; -.
DR BioGRID-ORCS; 40697; 1 hit in 1 CRISPR screen.
DR ChiTaRS; CG2182; fly.
DR GenomeRNAi; 40697; -.
DR PRO; PR:Q9VNG1; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037360; Expressed in oocyte and 24 other tissues.
DR ExpressionAtlas; Q9VNG1; baseline and differential.
DR Genevisible; Q9VNG1; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR026073; GGNBP2.
DR PANTHER; PTHR13601; PTHR13601; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..671
FT /note="Gametogenetin-binding protein 2-like"
FT /id="PRO_0000239354"
FT REGION 372..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..387
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..420
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..473
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..32
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_019182"
SQ SEQUENCE 671 AA; 77061 MW; B5176AA4A621BEF7 CRC64;
MARLTKVYNT DDDDSGYVGR RNLPLVAGDK LMMLMDLNSK GLVIDSPLIR GRELEEFSRK
FKLLTEAERR QSLEIDSASF MEVLNQCVQC VGCRRRVERL FHQLTETGHR TLDPLELRPT
ATLGIVEEKL KTPQALGTLL YRHHEVLNNL LDNKLRNKTR CVLHSLDAFR AKPFSETWRE
VWSAMKSNCR NELTIIETKE LHDVLENYLK KHKFCSGCRT KIERAYKILI GEISSKEKGY
AAQLYAHIRK CVPDQHIHVT TNKIEFLDAL IKRAEPEVNG SYSKLRERHA KTLEIAQEEV
LTCVGMIMYE RLRRIYVSLR EEERACQVLA AVGVHALCRS FDTFVEQKQG ISNLELLYQE
ISRAERAKQI KREQKKLKKK KKKDEKKNLL HRQCDDTEAN ESDEEEEELR NEELDLEEES
QMQHEELSDP GADDGIVIEA ARSPEPEPEL TSKPTKSKPK KQSKKKKQKK AAFTKMGNQK
QMQATARVQP LDADHDQLDV ASCISSSIAK TVGDKCEECL ASMPNCPCEQ DVRDSGYGSD
PPSHAGSRTS SAISSPEGSE VSCSDGLCNH DVHDEDSDDL LFYSHQSQLD HKFSLLQMWD
DFDEYDDKDE ETYYIPQEVV MAFKCHREQV QRKREELRAK LRANFERLCV QHGVQTQVQK
SKRTTSALVG Q
