ID   GGNB2_RAT               Reviewed;         696 AA.
AC   Q6GVH5;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Gametogenetin-binding protein 2;
DE   AltName: Full=Protein ZNF403;
GN   Name=Ggnbp2; Synonyms=Zfp403, Znf403;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BN/SsNHsdMCW;
RX   PubMed=15642376; DOI=10.1016/j.febslet.2004.10.112;
RA   Zhang J., Wang Y., Zhou Y., Cao Z., Huang P., Lu B.;
RT   "Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential
RT   interaction partners of testicular germ cell-specific protein GGN1.";
RL   FEBS Lett. 579:559-566(2005).
CC   -!- FUNCTION: May be involved in spermatogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GGN. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}.
CC       Note=Associated with vesicular structures. {ECO:0000250}.
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DR   EMBL; AY633742; AAT47121.1; -; mRNA.
DR   RefSeq; NP_001004273.1; NM_001004273.1.
DR   RefSeq; XP_017459590.1; XM_017604101.1.
DR   AlphaFoldDB; Q6GVH5; -.
DR   SMR; Q6GVH5; -.
DR   STRING; 10116.ENSRNOP00000049469; -.
DR   PaxDb; Q6GVH5; -.
DR   PRIDE; Q6GVH5; -.
DR   GeneID; 360584; -.
DR   KEGG; rno:360584; -.
DR   CTD; 79893; -.
DR   RGD; 1302978; Ggnbp2.
DR   VEuPathDB; HostDB:ENSRNOG00000027860; -.
DR   eggNOG; ENOG502QQ20; Eukaryota.
DR   HOGENOM; CLU_024870_0_0_1; -.
DR   InParanoid; Q6GVH5; -.
DR   OrthoDB; 398180at2759; -.
DR   PRO; PR:Q6GVH5; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000027860; Expressed in testis and 20 other tissues.
DR   ExpressionAtlas; Q6GVH5; baseline and differential.
DR   Genevisible; Q6GVH5; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR   GO; GO:0060716; P:labyrinthine layer blood vessel development; ISO:RGD.
DR   GO; GO:0060711; P:labyrinthine layer development; ISO:RGD.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR   GO; GO:0033140; P:negative regulation of peptidyl-serine phosphorylation of STAT protein; ISO:RGD.
DR   GO; GO:0061099; P:negative regulation of protein tyrosine kinase activity; ISO:RGD.
DR   GO; GO:0042532; P:negative regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR026073; GGNBP2.
DR   PANTHER; PTHR13601; PTHR13601; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Developmental protein; Differentiation;
KW   Phosphoprotein; Reference proteome; Spermatogenesis.
FT   CHAIN           1..696
FT                   /note="Gametogenetin-binding protein 2"
FT                   /id="PRO_0000239350"
FT   MOD_RES         360
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H3C7"
SQ   SEQUENCE   696 AA;  79009 MW;  3AA3FA7C45DA338F CRC64;
     MARLVAVCRD GEEEFPFERR QIPLYIDDTL TMVMEFPDNV LNLDGHQNNG AQLKQFIQRH
     SMLKQQDLSI AMVVTSREVL SALSQLVPCV GCRRSVERLF SQLVESGNPA LEPLTVGPKG
     VLSLTRSCMT DAKKLYTLFY VHGSKLNDMI DAIPKSKKNK RCQLHSLDTH KPKPLGGCWM
     DVWELMSQEC RDEVVLIDSS CLLETLETYL RKHRFCTDCK NKVLRAYNIL IGELDCSKEK
     GYCAALYEGL RCCPHERHIH VCCETDFIAH LLGRAEPEFA GGRRERHAKT IDIAQEEVLT
     CLGIHLYERL HRIWQKLRAE EQTWQMLFYL GVDALRKSFE MTVEKVQGIS RLEQLCEEFS
     EEERVRELKQ EKKRQKRKNR RKNKCVCDSP ASLHTADEKA VSQEKETDFM ENSCKACGST
     EDGNTCVEVI VTNENTSCTC PSSGNLLGSP KIKKGMSPHC NGSDCGYSSS MEGSETGSRE
     GSDVACTEGI CNHDEHGEDP CVHHCEDKED DGDSCVECWA NSEENNTKGK NKKKKKKSKM
     LKCDEHIQKL GSCITDPGNR ETSGNTMHTV FHRDKTKDAH PESCCSTEKG GQPLPWFEHR
     KNVPQFTEPT EMSFGPDSGK GAKSLVELLD ESECTSDEEI FISQDEIQSF MANNQSFYSN
     REQYRQHLKE KFNKYCRLND HKRPVCSGWL TTAGAN