ID   GGN_RAT                 Reviewed;         658 AA.
AC   Q66HC8;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Gametogenetin;
GN   Name=Ggn;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May be involved in spermatogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2. {ECO:0000250}.
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DR   EMBL; BC081922; AAH81922.1; -; mRNA.
DR   EMBL; BC100147; AAI00148.1; -; mRNA.
DR   RefSeq; NP_001013083.2; NM_001013065.1.
DR   RefSeq; NP_001296756.1; NM_001309827.1.
DR   RefSeq; XP_006228781.1; XM_006228719.3.
DR   AlphaFoldDB; Q66HC8; -.
DR   STRING; 10116.ENSRNOP00000053791; -.
DR   iPTMnet; Q66HC8; -.
DR   PhosphoSitePlus; Q66HC8; -.
DR   PaxDb; Q66HC8; -.
DR   GeneID; 292765; -.
DR   KEGG; rno:292765; -.
DR   UCSC; RGD:1306765; rat.
DR   CTD; 199720; -.
DR   RGD; 1306765; Ggn.
DR   VEuPathDB; HostDB:ENSRNOG00000023931; -.
DR   eggNOG; ENOG502ST22; Eukaryota.
DR   HOGENOM; CLU_031676_0_0_1; -.
DR   InParanoid; Q66HC8; -.
DR   OMA; PPGQMHS; -.
DR   OrthoDB; 1139345at2759; -.
DR   PhylomeDB; Q66HC8; -.
DR   PRO; PR:Q66HC8; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000023931; Expressed in testis and 17 other tissues.
DR   Genevisible; Q66HC8; RN.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; ISO:RGD.
DR   GO; GO:0007566; P:embryo implantation; ISO:RGD.
DR   GO; GO:0007276; P:gamete generation; ISO:RGD.
DR   GO; GO:0008104; P:protein localization; ISO:RGD.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR031400; GGN.
DR   PANTHER; PTHR47742; PTHR47742; 1.
DR   Pfam; PF15685; GGN; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; Phosphoprotein; Reference proteome;
KW   Spermatogenesis.
FT   CHAIN           1..658
FT                   /note="Gametogenetin"
FT                   /id="PRO_0000239344"
FT   REGION          1..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..491
FT                   /note="Interaction with GGNBP1"
FT                   /evidence="ECO:0000250"
FT   REGION          285..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          496..658
FT                   /note="Interactions with ZNF403/GGNBP2 and OAZ3"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        66..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..109
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..185
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..340
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..470
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        558..583
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         384
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   658 AA;  67501 MW;  FEC8BBF003753046 CRC64;
     MGNVQSEPSA GGGSRKEQAS DRASDSRRTP LVEPEVTPSS PAMRLARGLG VWFPGSSGPP
     GLLIPPESQA SSSTLPLTLE LPSPVTPPPE EAAAAAVSTP PPPPVGTLLP APSKWRKPTG
     TAVPRIRGLL EASHRGQGDP PSLRPLPPLP RQLTEKDPVL RAPAPPPTPL EPRKQLPPAP
     STCDPQPPSR RITLASSATS PTESQVRHSS EGQAAGGAHG EGEMARSATS ESGLSLLCKV
     TFKSGPHLSP TSSSGPLAAK ASLGASGGGG LFASSGAISY AEVLKQGPQP PGATRPLGEG
     PRAAQETEGG DGDGEGCSGP PSVPTPLARA LPPPPYTTFP GSKPKFDWVS PPDGTERHFR
     FNGAVGGIGA PRRRTTTLSG PWGSPPPRSG QTHPSSGPRR PTPALLAPPM FIFPAPNNGE
     PVRPVPPSPQ QIPPLPPPPP TPPATPPPAP PPTPQPPALP RTPILVARPP TPGPGHLESA
     LAPTPPSTLS PTAAAEQAPA PTPAPVTSQV PATTTAELSP PMPQPKIRTR RNKGPRAARG
     VIREEGTSGD GPREPNMAPV TDSSSGGGGG GSNGTSTAGA SNKGTARHWP PFEVLNSCPC
     KCYCRHQRRH RRLPRNVSAW LSTPTNHLSE PPWVATVKLA GSLVAGLEHY DLQATHST