GGTB2_CAEEL
ID GGTB2_CAEEL Reviewed; 335 AA.
AC P41992; Q2V4X4;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Probable geranylgeranyl transferase type-2 subunit beta;
DE EC=2.5.1.60;
DE AltName: Full=Geranylgeranyl transferase type II subunit beta;
DE Short=GGTase-II-beta;
DE AltName: Full=Rab geranyl-geranyltransferase subunit beta;
DE Short=Rab GG transferase beta;
DE Short=Rab GGTase beta;
DE AltName: Full=Rab geranylgeranyltransferase subunit beta;
DE AltName: Full=Type II protein geranyl-geranyltransferase subunit beta;
GN Name=ggtb-1; ORFNames=B0280.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from
CC geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an
CC -XXCC, -XCXC and -CCXX C-terminal. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC ChEBI:CHEBI:86021; EC=2.5.1.60;
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P41992-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P41992-2; Sequence=VSP_018160;
CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit beta
CC family. {ECO:0000305}.
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DR EMBL; FO080148; CCD61597.1; -; Genomic_DNA.
DR EMBL; FO080148; CCD61598.1; -; Genomic_DNA.
DR RefSeq; NP_498559.1; NM_066158.6. [P41992-1]
DR RefSeq; NP_741214.2; NM_171183.3. [P41992-2]
DR AlphaFoldDB; P41992; -.
DR SMR; P41992; -.
DR BioGRID; 41210; 3.
DR STRING; 6239.B0280.1a; -.
DR EPD; P41992; -.
DR PaxDb; P41992; -.
DR PeptideAtlas; P41992; -.
DR PRIDE; P41992; -.
DR EnsemblMetazoa; B0280.1a.1; B0280.1a.1; WBGene00015099. [P41992-1]
DR EnsemblMetazoa; B0280.1b.1; B0280.1b.1; WBGene00015099. [P41992-2]
DR EnsemblMetazoa; B0280.1b.2; B0280.1b.2; WBGene00015099. [P41992-2]
DR GeneID; 175998; -.
DR KEGG; cel:CELE_B0280.1; -.
DR UCSC; B0280.1a; c. elegans. [P41992-1]
DR CTD; 175998; -.
DR WormBase; B0280.1a; CE24762; WBGene00015099; ggtb-1. [P41992-1]
DR WormBase; B0280.1b; CE00735; WBGene00015099; ggtb-1. [P41992-2]
DR eggNOG; KOG0366; Eukaryota.
DR GeneTree; ENSGT00950000183128; -.
DR HOGENOM; CLU_028946_3_0_1; -.
DR InParanoid; P41992; -.
DR OMA; VKRCQCP; -.
DR OrthoDB; 1042804at2759; -.
DR PhylomeDB; P41992; -.
DR Reactome; R-CEL-6803205; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.
DR Reactome; R-CEL-8873719; RAB geranylgeranylation.
DR PRO; PR:P41992; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00015099; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; ISS:UniProtKB.
DR GO; GO:0004663; F:Rab geranylgeranyltransferase activity; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR GO; GO:0018344; P:protein geranylgeranylation; ISS:UniProtKB.
DR GO; GO:0018342; P:protein prenylation; IBA:GO_Central.
DR CDD; cd02894; GGTase-II; 1.
DR InterPro; IPR001330; PFTB_repeat.
DR InterPro; IPR045089; PGGT1B-like.
DR InterPro; IPR026873; Ptb1.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11774; PTHR11774; 1.
DR Pfam; PF00432; Prenyltrans; 5.
DR SUPFAM; SSF48239; SSF48239; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Metal-binding; Prenyltransferase; Reference proteome;
KW Repeat; Transferase; Zinc.
FT CHAIN 1..335
FT /note="Probable geranylgeranyl transferase type-2 subunit
FT beta"
FT /id="PRO_0000119766"
FT REPEAT 74..115
FT /note="PFTB 1"
FT REPEAT 122..163
FT /note="PFTB 2"
FT REPEAT 170..211
FT /note="PFTB 3"
FT REPEAT 218..259
FT /note="PFTB 4"
FT REPEAT 266..312
FT /note="PFTB 5"
FT BINDING 196..198
FT /ligand="geranylgeranyl diphosphate"
FT /ligand_id="ChEBI:CHEBI:57533"
FT /evidence="ECO:0000250"
FT BINDING 238..250
FT /ligand="geranylgeranyl diphosphate"
FT /ligand_id="ChEBI:CHEBI:57533"
FT /evidence="ECO:0000250"
FT BINDING 244
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 246
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 296
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT VAR_SEQ 292..335
FT /note="ADPFHTVFGIAALSLFGDDTLESVDPIFCMTKRCLGDKQVEMYY -> VSFL
FT NNIQKFIFVLQSNNVLATTKQLFECSFNNS (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_018160"
SQ SEQUENCE 335 AA; 37226 MW; F54AB54E58F9A67E CRC64;
MSFAGLLDFA RKDVDLPQNS PNELLKDLHA NFINQYEKNK NSYHYIMAEH LRVSGIYWCV
NAMDLSKQLE RMSTEEIVNY VLGCRNTDGG YGPAPGHDSH LLHTLCAVQT LIIFNSIEKA
DADTISEYVK GLQQEDGSFC GDLSGEVDTR FTLCSLATCH LLGRLSTLNI DSAVRFLMRC
YNTDGGFGTR PGSESHSGQI YCCVGALAIA GRLDEIDRDR TAEWLAFRQC DSGGLNGRPE
KLPDVCYSWW VLASLAILGR LNFIDSDAMK KFIYACQDDE TGGFADRPGD CADPFHTVFG
IAALSLFGDD TLESVDPIFC MTKRCLGDKQ VEMYY
