GGTC_SYNY3
ID GGTC_SYNY3 Reviewed; 279 AA.
AC Q55472;
DT 22-APR-2020, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Osmoprotective compounds uptake permease protein GgtC {ECO:0000305};
GN Name=ggtC {ECO:0000303|PubMed:11081796};
GN OrderedLocusNames=slr0530 {ECO:0000312|EMBL:BAA10818.1};
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
RN [2]
RP FUNCTION, SUBUNIT, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11081796; DOI=10.1007/s002030000201;
RA Mikkat S., Hagemann M.;
RT "Molecular analysis of the ggtBCD gene cluster of Synechocystis sp. strain
RT PCC6803 encoding subunits of an ABC transporter for osmoprotective
RT compounds.";
RL Arch. Microbiol. 174:273-282(2000).
CC -!- FUNCTION: Part of the ABC transporter complex GgtABCD involved in the
CC uptake of the osmoprotective compounds glucosylglycerol (GG), sucrose
CC and trehalose (PubMed:11081796). Responsible for the translocation of
CC the substrate across the membrane (Probable).
CC {ECO:0000269|PubMed:11081796, ECO:0000305}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (GgtA),
CC two transmembrane proteins (GgtC and GgtD) and a solute-binding protein
CC (GgtB). {ECO:0000305|PubMed:11081796}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expression is very low in cells grown in basal medium but
CC increases significantly after a salt shock.
CC {ECO:0000269|PubMed:11081796}.
CC -!- DISRUPTION PHENOTYPE: Inactivation of the gene results in loss of the
CC ability to take up glucosylglycerol and sucrose, as well as to
CC accumulate exogenous trehalose. Insertion causes leakage of
CC glucosylglycerol from the cells into the medium.
CC {ECO:0000269|PubMed:11081796}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; BA000022; BAA10818.1; -; Genomic_DNA.
DR PIR; S75971; S75971.
DR AlphaFoldDB; Q55472; -.
DR SMR; Q55472; -.
DR STRING; 1148.1001331; -.
DR TCDB; 3.A.1.1.32; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q55472; -.
DR EnsemblBacteria; BAA10818; BAA10818; BAA10818.
DR KEGG; syn:slr0530; -.
DR eggNOG; COG1175; Bacteria.
DR InParanoid; Q55472; -.
DR OMA; FMIVVTQ; -.
DR PhylomeDB; Q55472; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..279
FT /note="Osmoprotective compounds uptake permease protein
FT GgtC"
FT /id="PRO_0000449363"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00441"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00441"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00441"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00441"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00441"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00441"
FT DOMAIN 53..270
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 279 AA; 31091 MW; 1E21EFDFEA0BF754 CRC64;
MYVTPALLFL SAYLILPTLE TVYLSFFDGR SRNFVGLKNY VFAFTDHTML VAFRNNLLWL
VLVTGISVSL GLIIAVLVDK VRYEAIAKSI IFLPMAISFV GASVIWKFVY AYRPAGAEQI
GLLNAIVTSL GFAPVGWLVE RSVNNFALIA IMIWLYTGFC MVILSAAVKG IPADVIEAAR
IDGANSWQIF WRITIPMIRS TLLVVSTTMV ILVLKVFDIV FVMTGGNQGT EVIASLMIKE
MFNYRNFGRG STIAVILLLL IVPVMITNIR RFKAQEKLR
