GGTL1_HUMAN
ID GGTL1_HUMAN Reviewed; 225 AA.
AC Q9BX51; D3DW43; Q08246;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Glutathione hydrolase light chain 1;
DE AltName: Full=Gamma-glutamyltransferase light chain 1;
DE AltName: Full=Gamma-glutamyltransferase-like activity 4;
DE AltName: Full=Gamma-glutamyltransferase-like protein 6;
GN Name=GGTLC1; Synonyms=GGTLA4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=7689219; DOI=10.1073/pnas.90.16.7461;
RA Wetmore L.A., Gerard C., Drazen J.M.;
RT "Human lung expresses unique gamma-glutamyl transpeptidase transcripts.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:7461-7465(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NOMENCLATURE.
RX PubMed=18357469; DOI=10.1007/s00439-008-0487-7;
RA Heisterkamp N., Groffen J., Warburton D., Sneddon T.P.;
RT "The human gamma-glutamyltransferase gene family.";
RL Hum. Genet. 123:321-332(2008).
CC -!- MISCELLANEOUS: Corresponds to the light chain of other gamma-
CC glutamyltransferase family members. Has no catalytic activity.
CC -!- SIMILARITY: Belongs to the gamma-glutamyltransferase family.
CC {ECO:0000305}.
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DR EMBL; L20491; AAA02885.1; -; mRNA.
DR EMBL; L20492; AAA35864.1; -; mRNA.
DR EMBL; AL133466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10125.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10129.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10130.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10131.1; -; Genomic_DNA.
DR EMBL; BC040904; AAH40904.1; -; mRNA.
DR CCDS; CCDS13163.1; -.
DR PIR; B47739; B47739.
DR RefSeq; NP_842563.1; NM_178311.2.
DR RefSeq; NP_842564.1; NM_178312.2.
DR RefSeq; XP_005260922.1; XM_005260865.4.
DR RefSeq; XP_016883615.1; XM_017028126.1.
DR AlphaFoldDB; Q9BX51; -.
DR SMR; Q9BX51; -.
DR BioGRID; 124906; 9.
DR IntAct; Q9BX51; 1.
DR STRING; 9606.ENSP00000337587; -.
DR MEROPS; T03.006; -.
DR MEROPS; T03.016; -.
DR GlyConnect; 1259; 8 N-Linked glycans (1 site).
DR GlyGen; Q9BX51; 1 site, 8 N-linked glycans (1 site).
DR BioMuta; GGTLC1; -.
DR DMDM; 34395714; -.
DR jPOST; Q9BX51; -.
DR MassIVE; Q9BX51; -.
DR MaxQB; Q9BX51; -.
DR PaxDb; Q9BX51; -.
DR PeptideAtlas; Q9BX51; -.
DR PRIDE; Q9BX51; -.
DR ProteomicsDB; 79349; -.
DR Antibodypedia; 9845; 70 antibodies from 20 providers.
DR DNASU; 92086; -.
DR Ensembl; ENST00000278765.8; ENSP00000278765.4; ENSG00000149435.12.
DR Ensembl; ENST00000286890.8; ENSP00000286890.4; ENSG00000149435.12.
DR Ensembl; ENST00000335694.4; ENSP00000337587.4; ENSG00000149435.12.
DR GeneID; 92086; -.
DR KEGG; hsa:92086; -.
DR MANE-Select; ENST00000335694.4; ENSP00000337587.4; NM_178311.3; NP_842563.1.
DR UCSC; uc002wts.3; human.
DR CTD; 92086; -.
DR DisGeNET; 92086; -.
DR GeneCards; GGTLC1; -.
DR HGNC; HGNC:16437; GGTLC1.
DR HPA; ENSG00000149435; Group enriched (lung, testis).
DR MIM; 612338; gene.
DR neXtProt; NX_Q9BX51; -.
DR OpenTargets; ENSG00000149435; -.
DR PharmGKB; PA28671; -.
DR VEuPathDB; HostDB:ENSG00000149435; -.
DR eggNOG; KOG2410; Eukaryota.
DR GeneTree; ENSGT00940000154601; -.
DR HOGENOM; CLU_014813_1_3_1; -.
DR InParanoid; Q9BX51; -.
DR OMA; HRERGHE; -.
DR PhylomeDB; Q9BX51; -.
DR PathwayCommons; Q9BX51; -.
DR SignaLink; Q9BX51; -.
DR BioGRID-ORCS; 92086; 247 hits in 988 CRISPR screens.
DR GenomeRNAi; 92086; -.
DR Pharos; Q9BX51; Tbio.
DR PRO; PR:Q9BX51; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BX51; protein.
DR Bgee; ENSG00000149435; Expressed in right lung and 31 other tissues.
DR Genevisible; Q9BX51; HS.
DR GO; GO:0036374; F:glutathione hydrolase activity; IEA:InterPro.
DR GO; GO:0006751; P:glutathione catabolic process; IEA:InterPro.
DR GO; GO:1901750; P:leukotriene D4 biosynthetic process; ISS:UniProtKB.
DR Gene3D; 3.60.20.40; -; 1.
DR InterPro; IPR000101; GGT_peptidase.
DR InterPro; IPR043137; GGT_ssub.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS00462; G_GLU_TRANSPEPTIDASE; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..225
FT /note="Glutathione hydrolase light chain 1"
FT /id="PRO_0000205983"
FT ACT_SITE 37
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT BINDING 55
FT /ligand="L-glutamate"
FT /ligand_id="ChEBI:CHEBI:29985"
FT /evidence="ECO:0000250"
FT BINDING 76
FT /ligand="L-glutamate"
FT /ligand_id="ChEBI:CHEBI:29985"
FT /evidence="ECO:0000250"
FT BINDING 107..108
FT /ligand="L-glutamate"
FT /ligand_id="ChEBI:CHEBI:29985"
FT /evidence="ECO:0000250"
FT BINDING 129..130
FT /ligand="L-glutamate"
FT /ligand_id="ChEBI:CHEBI:29985"
FT /evidence="ECO:0000250"
SQ SEQUENCE 225 AA; 24274 MW; 126947D3DBBE7536 CRC64;
MTSEFFSAQL RAQISDDTTH PISYYKPEFY MPDDGGTAHL SVVAEDGSAV SATSTINLYF
GSKVRSPVSG ILLNNEMDDF SSTSITNEFG VPPSPANFIQ PGKQPLSSMC PTIMVGQDGQ
VRMVVGAAGG TQITMATALA IIYNLWFGYD VKWAVEEPRL HNQLLPNVTT VERNIDQEVT
AALETRHHHT QITSTFIAVV QAIVRMAGGW AAASDSRKGG EPAGY
