ID   GGYF2_XENLA             Reviewed;        1239 AA.
AC   Q5U236;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=GRB10-interacting GYF protein 2;
DE   AltName: Full=PERQ amino acid-rich with GYF domain-containing protein 2;
GN   Name=gigyf2; Synonyms=perq2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key component of the 4EHP-GYF2 complex, a multiprotein
CC       complex that acts as a repressor of translation initiation.
CC       {ECO:0000250|UniProtKB:Q6Y7W6, ECO:0000250|UniProtKB:Q6Y7W8}.
CC   -!- SUBUNIT: Component of the 4EHP-GYF2 complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q6Y7W6, ECO:0000250|UniProtKB:Q6Y7W8}.
CC   -!- SIMILARITY: Belongs to the GIGYF family. {ECO:0000305}.
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DR   EMBL; BC086295; AAH86295.1; -; mRNA.
DR   RefSeq; NP_001088645.1; NM_001095176.1.
DR   AlphaFoldDB; Q5U236; -.
DR   SMR; Q5U236; -.
DR   BioGRID; 105778; 1.
DR   IntAct; Q5U236; 1.
DR   GeneID; 495698; -.
DR   KEGG; xla:495698; -.
DR   CTD; 495698; -.
DR   Xenbase; XB-GENE-5870341; gigyf2.S.
DR   OrthoDB; 412069at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 495698; Expressed in testis and 19 other tissues.
DR   CDD; cd00072; GYF; 1.
DR   Gene3D; 3.30.1490.40; -; 1.
DR   InterPro; IPR003169; GYF.
DR   InterPro; IPR035445; GYF-like_dom_sf.
DR   Pfam; PF02213; GYF; 1.
DR   SMART; SM00444; GYF; 1.
DR   SUPFAM; SSF55277; SSF55277; 1.
DR   PROSITE; PS50829; GYF; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..1239
FT                   /note="GRB10-interacting GYF protein 2"
FT                   /id="PRO_0000270840"
FT   DOMAIN          488..536
FT                   /note="GYF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00101"
FT   REGION          105..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          678..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          763..812
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          843..960
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1057..1085
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..184
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..226
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..276
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..309
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..364
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        843..866
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        867..911
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        913..931
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        932..960
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1060..1079
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1239 AA;  141636 MW;  9C55179440DC8301 CRC64;
     MTAETQTLNF GPEWLRALSS GGSVISPPLS PALPKYKLAD FRYGREEMLA LYVKDNKVPS
     DLLDKEFLPI LNDEPLLPLA LVSFTEEEQR NFSMSVNSAA VLRLTNRGSS GGGGTVVGVP
     RGRSSSRGRG RGRGESGFYQ RSFDEVESGF GRGAREMHRS QSWEERGDRR FEKPARKEPD
     GVRGSAWREI PDRRRRFDYD LRESKDERGY RRPRSGSGIA EDERDSLPEW CLDDAEDETG
     TFDSSGAFLS SKPSKKVQKE PIPEEQEIDF HPSVDGAEVS DSDGSQTEEA KETDPVQSQN
     QDDDLSRNDH TVQAAPSPDH KTSSPVRRTD MTLDTAHQKA VSPHLSCKMD AKSQSPSSPP
     TPSKHKEDAA SASHQGTREK AGPCLPHPQS PALSQRSPAR QPDPHIVPAM SSVPVPQLDT
     PTVPIHSSVC AAPGMEPVPP EPDEDGLEHL EQQAQQMVAY LQDGTLDDDH LLTKVLDQRV
     KGPSLDNQQK WYYKDPQGEI QGPFSNREMA EWYQAGYFPM TLLLRRVCDE TFQPLGDIFK
     KWGRVPFSTP PTPRLGDLDP ERLSRQQEIT ALYQMRHLHY QQLLFQQQYA VLAQQQKVAL
     SSQQQQLPLP LQPLSMRIPE HTVIPPVVRA LSVPESTSLW ELPPAPTQPA VWEGSSVWDL
     PVEPTTQGTT REQLAQMDKV KAAKMEQERR EAELRAKQEE EEQHRRKEAE EERKRREEEE
     LARRKQEEAL QRQKELALQK QMEEEERQRK KELQLLEERM RQEEERKRLE EERRRQEEER
     RKQLEERKRA EEERRRREEE KKREEDERRQ LEEIQRKQEE AARWAREEEE AVRLLLEEAR
     LKAEEEERNK REEAQRQKEL QRQRQQQQEA LRRLQLQQQQ QQLAQMKLPS SSTWGQQVTP
     SAASQSALSL AEIQKLEEER ERQKLQEQRH QQQELKALQQ QQQQQQQKIP GWGTMSKPTG
     TTKSLLEIQQ EEAGQMQKNH QQPGRNRPAN ISLPVAPVVN NHISSPTVGN SGSSVWGSLN
     NNLSPQWSSD SMSSIWGSTD VKGSSVGFWD DAVKEVAPRN ATSKNKNNAS KSAGSNSRQS
     KKVEQEEKLL RLFQGANKCQ DDFTQWCEKT MHAINTAHSL DVPTFVSFLR EVESPYEVHD
     YVCAYLGDTP EAKDFSKQFI ERRTKQKTSQ HRPQQDVAWV TCQTSQANSQ PITLEAVQCA
     GRKKKKQKMV RADPSLLGFS VNASSERLNM GEIETAEDY