GG_HHV11
ID GG_HHV11 Reviewed; 238 AA.
AC P06484; Q770H5;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 23-FEB-2022, entry version 87.
DE RecName: Full=Envelope glycoprotein G;
DE Short=gG;
DE AltName: Full=gG-1;
DE Flags: Precursor;
GN Name=gG; ORFNames=US4;
OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX NCBI_TaxID=10299;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2984429; DOI=10.1016/0022-2836(85)90320-1;
RA McGeoch D.J., Dolan A., Donald S., Rixon F.J.;
RT "Sequence determination and genetic content of the short unique region in
RT the genome of herpes simplex virus type 1.";
RL J. Mol. Biol. 181:1-13(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2846760; DOI=10.1099/0022-1317-69-11-2831;
RA Perry L.J., McGeoch D.J.;
RT "The DNA sequences of the long repeat region and adjoining parts of the
RT long unique region in the genome of herpes simplex virus type 1.";
RL J. Gen. Virol. 69:2831-2846(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10548571; DOI=10.1128/cdli.6.6.826-831.1999;
RA Rekabdar E., Tunback P., Liljeqvist J.-A., Bergstroem T.;
RT "Variability of the glycoprotein G gene in clinical isolates of herpes
RT simplex virus type 1.";
RL Clin. Diagn. Lab. Immunol. 6:826-831(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005,
RC Isolate SK013, Isolate SK027, Isolate SK095, and Isolate SK098;
RX PubMed=16376841; DOI=10.1016/j.meegid.2005.01.004;
RA Bowden R., Sakaoka H., Ward R., Donnelly P.;
RT "Patterns of Eurasian HSV-1 molecular diversity and inferences of human
RT migrations.";
RL Infect. Genet. Evol. 6:63-74(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nonneuroinvasive mutant HF10;
RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT "Determination and analysis of the DNA sequence of highly attenuated herpes
RT simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL Microbes Infect. 9:142-149(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17 syn+;
RA Cunningham C., Davison A.J.;
RT "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP SUBCELLULAR LOCATION.
RC STRAIN=F;
RX PubMed=18596102; DOI=10.1128/jvi.00904-08;
RA Loret S., Guay G., Lippe R.;
RT "Comprehensive characterization of extracellular herpes simplex virus type
RT 1 virions.";
RL J. Virol. 82:8605-8618(2008).
CC -!- FUNCTION: Chemokine-binding protein that inhibits neutrophils'
CC chemotaxis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein G family.
CC {ECO:0000305}.
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DR EMBL; L00036; AAA96684.1; -; Genomic_DNA.
DR EMBL; X14112; CAA32281.1; -; Genomic_DNA.
DR EMBL; X02138; CAA26058.1; -; Genomic_DNA.
DR EMBL; AF117122; AAD33228.1; -; Genomic_DNA.
DR EMBL; AY240789; AAP39675.1; -; Genomic_DNA.
DR EMBL; AY240790; AAP39678.1; -; Genomic_DNA.
DR EMBL; AY240791; AAP39681.1; -; Genomic_DNA.
DR EMBL; AY240794; AAP39690.1; -; Genomic_DNA.
DR EMBL; AY240801; AAP39711.1; -; Genomic_DNA.
DR EMBL; AY240811; AAP39741.1; -; Genomic_DNA.
DR EMBL; AY240820; AAP39768.1; -; Genomic_DNA.
DR EMBL; AY240823; AAP39777.1; -; Genomic_DNA.
DR EMBL; DQ889502; ABI63522.1; -; Genomic_DNA.
DR EMBL; FJ593289; ACM62293.1; -; Genomic_DNA.
DR PIR; A05239; QQBE74.
DR RefSeq; YP_009137139.1; NC_001806.2.
DR SMR; P06484; -.
DR BioGRID; 971434; 32.
DR ChEMBL; CHEMBL2364696; -.
DR DrugCentral; P06484; -.
DR PRIDE; P06484; -.
DR DNASU; 2703401; -.
DR GeneID; 2703401; -.
DR GeneID; 2703404; -.
DR KEGG; vg:2703404; -.
DR PRO; PR:P06484; -.
DR Proteomes; UP000009294; Genome.
DR Proteomes; UP000180652; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Viral envelope protein; Virion.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..238
FT /note="Envelope glycoprotein G"
FT /id="PRO_0000115767"
FT TOPO_DOM 25..189
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..238
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT REGION 28..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..143
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 238 AA; 25239 MW; F7FDC2867E834B92 CRC64;
MSQGAMRAVV PIIPFLLVLV GVSGVPTNVS STTQPQLQTT GRPSHEAPNM TQTGTTDSPT
AISLTTPDHT PPMPSIGLEE EEEEEGAGDG EHLEGGDGTR DTLPQSPGPA FPLAEDVEKD
KPNRPVVPSP DPNNSPARPE TSRPKTPPTI IGPLATRPTT RLTSKGRPLV PTPQHTPLFS
FLTASPALDT LFVVSTVIHT LSFLCIGAMA THLCGGWSRR GRRTHPSVRY VCLPSERG
