ID   GG_SUHVR                Reviewed;         498 AA.
AC   P07562;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Envelope glycoprotein G;
DE            Short=gG;
DE   Flags: Precursor;
GN   Name=gG; OrderedLocusNames=70;
OS   Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain
OS   Rice)).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10350;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2983115; DOI=10.1128/jvi.54.1.21-29.1985;
RA   Rea T.J., Timmins J.G., Long G.W., Post L.E.;
RT   "Mapping and sequence of the gene for the pseudorabies virus glycoprotein
RT   which accumulates in the medium of infected cells.";
RL   J. Virol. 54:21-29(1985).
CC   -!- FUNCTION: Chemokine-binding protein that inhibits neutrophils'
CC       chemotaxis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein G family.
CC       {ECO:0000305}.
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DR   EMBL; M10986; AAC35206.1; -; Genomic_DNA.
DR   PIR; A21879; VGBEGX.
DR   RefSeq; YP_068386.1; NC_006151.1.
DR   GeneID; 2952520; -.
DR   KEGG; vg:2952520; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039553; P:suppression by virus of host chemokine activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002896; Herpes_glycop_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   Pfam; PF01537; Herpes_glycop_D; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host-virus interaction;
KW   Inhibition of host chemokines by virus; Membrane; Repeat; Signal;
KW   Transmembrane; Transmembrane helix; Viral envelope protein;
KW   Viral immunoevasion; Virion.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..498
FT                   /note="Envelope glycoprotein G"
FT                   /id="PRO_0000115788"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          271..292
FT                   /note="1"
FT   REPEAT          308..329
FT                   /note="2"
FT   REGION          271..329
FT                   /note="2 X 22 AA repeats of E-E-[DE]-[AE]-E-L-T-S-S-D-L-D-
FT                   N-I-E-I-E-V-V-G-S-P"
FT   REGION          290..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..318
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        142
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        226
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        443
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  53722 MW;  17DEA180672A62DD CRC64;
     MKWATWILAL GLLVVRTVVA REAPRELCYG HPVHDDRRPV GPATDAQPVN PLAPANATGT
     DYSRGCEMRL LDPPLDVSSR SSDPVNVTVA WFFDGGHCKV PLVHREYYGC PGDAMPSVET
     CTGGYSYTRT RIDTLMEYAL VNASLVLQPG LYDAGLYIVV LVFGDDAYLG TVSLSVEANL
     DYPCGMKHGL TITRPGATLP PIAPTAGDHQ RWRGCFPSTD EGAWENVTAA EKGLSDDYAD
     YYDVHIFRSE SDDEVVHGDA PEAPEGEEVT EEEAELTSSD LDNIEIEVVG SPAAPAEGPA
     TEEGRGAEED EELTSSDLDN IEIEVVGSPR PPASSPPPPP PRPHPRGRDH DHDHGHHRAD
     DRGPQRHHRL PPEPTFVSPS DIFVTPTGSP ALLLGFLGSA LASRPLHLTA GETAQHVREA
     QQKSRHIRSL GGLQLSVETE TTNTTTTQTG LSGDIRTSIY ICVALAGLVV VGIVIMCLHM
     AIIRARARND GYRHVASA