ID   3S11_BUNFA              Reviewed;          64 AA.
AC   P10808;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Short neurotoxin 1;
DE   AltName: Full=Toxin V-II-1;
OS   Bungarus fasciatus (Banded krait) (Pseudoboa fasciata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=8613;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=2738048; DOI=10.1093/oxfordjournals.jbchem.a122626;
RA   Liu C.-S., Chen J.-P., Chang C.-S., Lo T.-B.;
RT   "Amino acid sequence of a short chain neurotoxin from the venom of banded
RT   krait (Bungarus fasciatus).";
RL   J. Biochem. 105:93-97(1989).
CC   -!- FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and
CC       inhibit acetylcholine from binding to the receptor, thereby impairing
CC       neuromuscular transmission. {ECO:0000250|UniProtKB:P60775}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2738048}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR   PIR; JX0060; JX0060.
DR   AlphaFoldDB; P10808; -.
DR   SMR; P10808; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..64
FT                   /note="Short neurotoxin 1"
FT                   /evidence="ECO:0000269|PubMed:2738048"
FT                   /id="PRO_0000093571"
FT   DISULFID        3..26
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        20..43
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        45..56
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        57..62
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
SQ   SEQUENCE   64 AA;  7272 MW;  340A6AF40F5E06D5 CRC64;
     RICLNQQQST PEDQPTNGQC YIKTDCQNKT WNTHRGSRTD RGCGCPKVKP GINLRCCKTD
     KCNE