GHDC_MOUSE
ID GHDC_MOUSE Reviewed; 532 AA.
AC Q99J23; A2A5D7; Q99J92;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=GH3 domain-containing protein;
DE Flags: Precursor;
GN Name=Ghdc; Synonyms=D11lgp1e, Lgp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=11161808; DOI=10.1006/geno.2000.6433;
RA Miyoshi K., Cui Y., Riedlinger G., Robinson P., Lehoczky J., Zon L.,
RA Oka T., Dewar K., Hennighausen L.;
RT "Structure of the mouse Stat 3/5 locus: evolution from Drosophila to
RT zebrafish to mouse.";
RL Genomics 71:150-155(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11735219; DOI=10.1006/geno.2001.6661;
RA Cui Y., Li M., Walton K.D., Sun K., Hanover J.A., Furth P.A.,
RA Hennighausen L.;
RT "The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like
RT proteins that are preferentially expressed in normal and neoplastic mammary
RT tissue.";
RL Genomics 78:129-134(2001).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:11735219}. Nucleus envelope
CC {ECO:0000269|PubMed:11735219}.
CC -!- TISSUE SPECIFICITY: Highly expressed in mammary tissues from mature
CC virgins and at day 13 of pregnancy, and at lower level during
CC lactation. Expressed at intermediate level in liver. Expressed at lower
CC level in kidney, heart and brain. {ECO:0000269|PubMed:11735219}.
CC -!- SIMILARITY: Belongs to the GH3 family. {ECO:0000305}.
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DR EMBL; AF316996; AAK15471.1; -; mRNA.
DR EMBL; AF316998; AAK15473.1; -; Genomic_DNA.
DR EMBL; AL591466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005639; AAH05639.1; -; mRNA.
DR CCDS; CCDS25437.1; -.
DR RefSeq; NP_114077.1; NM_031871.1.
DR AlphaFoldDB; Q99J23; -.
DR SMR; Q99J23; -.
DR STRING; 10090.ENSMUSP00000017891; -.
DR GlyGen; Q99J23; 2 sites.
DR iPTMnet; Q99J23; -.
DR PhosphoSitePlus; Q99J23; -.
DR SwissPalm; Q99J23; -.
DR MaxQB; Q99J23; -.
DR PaxDb; Q99J23; -.
DR PRIDE; Q99J23; -.
DR ProteomicsDB; 271219; -.
DR Antibodypedia; 29163; 92 antibodies from 24 providers.
DR Ensembl; ENSMUST00000017891; ENSMUSP00000017891; ENSMUSG00000017747.
DR GeneID; 80860; -.
DR KEGG; mmu:80860; -.
DR UCSC; uc007lmh.1; mouse.
DR CTD; 84514; -.
DR MGI; MGI:1931556; Ghdc.
DR VEuPathDB; HostDB:ENSMUSG00000017747; -.
DR eggNOG; ENOG502QPMW; Eukaryota.
DR GeneTree; ENSGT00390000016401; -.
DR HOGENOM; CLU_038581_1_0_1; -.
DR InParanoid; Q99J23; -.
DR OMA; IGPAQVH; -.
DR OrthoDB; 374623at2759; -.
DR TreeFam; TF333007; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 80860; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ghdc; mouse.
DR PRO; PR:Q99J23; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q99J23; protein.
DR Bgee; ENSMUSG00000017747; Expressed in saccule of membranous labyrinth and 125 other tissues.
DR ExpressionAtlas; Q99J23; baseline and differential.
DR Genevisible; Q99J23; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IBA:GO_Central.
DR InterPro; IPR004993; GH3.
DR PANTHER; PTHR31901; PTHR31901; 1.
DR Pfam; PF03321; GH3; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Nucleus; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..532
FT /note="GH3 domain-containing protein"
FT /id="PRO_0000021594"
FT REGION 100..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 356
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 451
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 25
FT /note="S -> A (in Ref. 3; AAH05639)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 532 AA; 58508 MW; A673D817A54CB7AC CRC64;
MLLLWLLLLL LLLVPLLAIL WQQRSRGARP CWLISLQHRV AWGMLGWAAA WQQWRLDRST
LNVGQSQQQA LMWCLKKAQG SCCLPREDTD MRTFRNHLPL TQTSHTQEQE SEETLPSPAS
PQYHGDASLQ ATLLGLITLN KAYPEALAPG STACVTPTSP WPCSVPWLGH ALGRVSPDGA
KDPRTLLLEA LISPGLRVLE ARTAVELLDV FVGLEADGEE LAEAIAAGIL GTLLPKRAAE
LKEALEQGPR GLARRLWPKL QVVVTLDSGG QAEAVAALRV LWCQGLAFFS PAYAASGGVV
ALNLWPERPQ GSYLLPPGVP FIELLPIKEG TQEEAASTLL LTDAQREKEY ELVLTNHTSL
TRCRLGDVVQ VVGTYNQCPV VRFTCRLGQT LNVRGEVTDE TVFSVALAQA VGQWPGAKLL
DHVCVESRVL DSCEGSAPHY EVFVELRGLR NLSEENRDKL DNCLQEASAQ YKSLRFRGSV
GPAKVHLVRP GSFRVLREAL AAFSSSSCRP PEMPRVIRLR HLAQLLQKRV IS
