ID   GHITM_RAT               Reviewed;         346 AA.
AC   Q5XIA8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Growth hormone-inducible transmembrane protein;
DE   AltName: Full=Mitochondrial morphology and cristae structure 1;
DE            Short=MICS1;
DE   Flags: Precursor;
GN   Name=Ghitm; Synonyms=Mics1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for the mitochondrial tubular network and cristae
CC       organization. Involved in apoptotic release of cytochrome c (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC083778; AAH83778.1; -; mRNA.
DR   RefSeq; NP_001005908.1; NM_001005908.1.
DR   RefSeq; XP_006252848.1; XM_006252786.2.
DR   AlphaFoldDB; Q5XIA8; -.
DR   STRING; 10116.ENSRNOP00000018723; -.
DR   PaxDb; Q5XIA8; -.
DR   PRIDE; Q5XIA8; -.
DR   Ensembl; ENSRNOT00000106368; ENSRNOP00000077387; ENSRNOG00000013961.
DR   GeneID; 290596; -.
DR   KEGG; rno:290596; -.
DR   UCSC; RGD:1359301; rat.
DR   CTD; 27069; -.
DR   RGD; 1359301; Ghitm.
DR   eggNOG; KOG1630; Eukaryota.
DR   GeneTree; ENSGT01050000244940; -.
DR   HOGENOM; CLU_050797_1_0_1; -.
DR   InParanoid; Q5XIA8; -.
DR   OMA; MYGTFYT; -.
DR   OrthoDB; 1228054at2759; -.
DR   PhylomeDB; Q5XIA8; -.
DR   TreeFam; TF314017; -.
DR   PRO; PR:Q5XIA8; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000013961; Expressed in heart and 19 other tissues.
DR   Genevisible; Q5XIA8; RN.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISO:RGD.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; ISO:RGD.
DR   GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISO:RGD.
DR   CDD; cd10431; GHITM; 1.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   InterPro; IPR035871; GHITM.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..45
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           46..346
FT                   /note="Growth hormone-inducible transmembrane protein"
FT                   /id="PRO_0000402543"
FT   TOPO_DOM        46..83
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..126
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..160
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..191
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        213..214
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        236..245
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        267..272
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..346
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   346 AA;  37178 MW;  23537F3F25E5A914 CRC64;
     MLAARLVCLR TLPSRVFQPT FITKASPLVK NSITKNQWLL TPSREYATKT RIRTHRGKTG
     QELKEAALEP SLEKVFKIDQ MGKWFVAGGA AVGLGALCYY GLGMSNEIGA IEKAVIWPQY
     VKDRIHSTYM YLAGSIGLTA LSALALARSP ALMNFMMTGS WMTIGATFAA MIGAGMLVQS
     ISYEQSPGPK HLAWMLHSGV MGAVVAPLTI LGGPLLLRAA WYTAGIVGGL STVAMCAPSE
     KFLNMGAPLG VGLGLVFASS LGSMFLPPTS VAGATLYSVA MYGGLVLFSM FLLYDTQKVV
     KRAEITPAYG AQKYDPINSM LTIYMDTLNI FMRVATMLAT GSNRKK