GHRHR_RAT
ID GHRHR_RAT Reviewed; 464 AA.
AC Q02644;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Growth hormone-releasing hormone receptor;
DE Short=GHRH receptor;
DE AltName: Full=Growth hormone-releasing factor receptor;
DE Short=GRF receptor;
DE Short=GRFR;
DE Flags: Precursor;
GN Name=Ghrhr; Synonyms=Grfr;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=1333056; DOI=10.1210/mend.6.10.1333056;
RA Mayo K.E.;
RT "Molecular cloning and expression of a pituitary-specific receptor for
RT growth hormone-releasing hormone.";
RL Mol. Endocrinol. 6:1734-1744(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1334535; DOI=10.1038/360765a0;
RA Lin C.R., Lin S.-C., Chang C.P., Rosenfeld M.G.;
RT "Pit-1-dependent expression of the receptor for growth hormone releasing
RT factor mediates pituitary cell growth.";
RL Nature 360:765-768(1992).
CC -!- FUNCTION: Receptor for GRF, coupled to G proteins which activate
CC adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone
CC gene transcription and growth hormone secretion.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=Q02644-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q02644-2; Sequence=VSP_002003;
CC -!- TISSUE SPECIFICITY: Pituitary gland.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000305}.
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DR EMBL; L01407; AAA41221.1; -; mRNA.
DR EMBL; L07380; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; S29754; S29754.
DR RefSeq; NP_036982.1; NM_012850.1. [Q02644-2]
DR AlphaFoldDB; Q02644; -.
DR SMR; Q02644; -.
DR STRING; 10116.ENSRNOP00000016087; -.
DR BindingDB; Q02644; -.
DR ChEMBL; CHEMBL3709; -.
DR GuidetoPHARMACOLOGY; 247; -.
DR GlyGen; Q02644; 1 site.
DR PhosphoSitePlus; Q02644; -.
DR PaxDb; Q02644; -.
DR GeneID; 25321; -.
DR KEGG; rno:25321; -.
DR UCSC; RGD:2688; rat. [Q02644-1]
DR CTD; 2692; -.
DR RGD; 2688; Ghrhr.
DR VEuPathDB; HostDB:ENSRNOG00000011808; -.
DR eggNOG; KOG4564; Eukaryota.
DR HOGENOM; CLU_002753_4_4_1; -.
DR InParanoid; Q02644; -.
DR OMA; RFYIELC; -.
DR OrthoDB; 651627at2759; -.
DR PhylomeDB; Q02644; -.
DR TreeFam; TF315710; -.
DR Reactome; R-RNO-420092; Glucagon-type ligand receptors.
DR PRO; PR:Q02644; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000011808; Expressed in kidney and 10 other tissues.
DR ExpressionAtlas; Q02644; baseline and differential.
DR Genevisible; Q02644; RN.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0005637; C:nuclear inner membrane; ISO:RGD.
DR GO; GO:0016363; C:nuclear matrix; ISO:RGD.
DR GO; GO:0005640; C:nuclear outer membrane; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0042383; C:sarcolemma; IDA:RGD.
DR GO; GO:0030141; C:secretory granule; ISO:RGD.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0019838; F:growth factor binding; ISO:RGD.
DR GO; GO:0016520; F:growth hormone-releasing hormone receptor activity; IDA:RGD.
DR GO; GO:0017046; F:peptide hormone binding; ISO:RGD.
DR GO; GO:0007190; P:activation of adenylate cyclase activity; IDA:RGD.
DR GO; GO:0021984; P:adenohypophysis development; ISO:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0019933; P:cAMP-mediated signaling; IDA:RGD.
DR GO; GO:0048469; P:cell maturation; ISO:RGD.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
DR GO; GO:0032869; P:cellular response to insulin stimulus; ISO:RGD.
DR GO; GO:0008340; P:determination of adult lifespan; ISO:RGD.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0030252; P:growth hormone secretion; IEA:Ensembl.
DR GO; GO:0042445; P:hormone metabolic process; ISO:RGD.
DR GO; GO:0007595; P:lactation; ISO:RGD.
DR GO; GO:0030879; P:mammary gland development; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0046010; P:positive regulation of circadian sleep/wake cycle, non-REM sleep; IMP:RGD.
DR GO; GO:0060124; P:positive regulation of growth hormone secretion; IMP:RGD.
DR GO; GO:0046887; P:positive regulation of hormone secretion; ISO:RGD.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; ISO:RGD.
DR GO; GO:0040008; P:regulation of growth; TAS:RGD.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0033143; P:regulation of intracellular steroid hormone receptor signaling pathway; ISO:RGD.
DR GO; GO:0051246; P:regulation of protein metabolic process; ISO:RGD.
DR GO; GO:0043627; P:response to estrogen; ISO:RGD.
DR GO; GO:0051384; P:response to glucocorticoid; ISO:RGD.
DR GO; GO:0032868; P:response to insulin; ISO:RGD.
DR GO; GO:0007165; P:signal transduction; IDA:RGD.
DR GO; GO:0060133; P:somatotropin secreting cell development; ISO:RGD.
DR GO; GO:0030104; P:water homeostasis; ISO:RGD.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003288; GPCR_2_GHRH_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF14; PTHR45620:SF14; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR01352; GHRHRECEPTOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF111418; SSF111418; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..464
FT /note="Growth hormone-releasing hormone receptor"
FT /id="PRO_0000012831"
FT TOPO_DOM 23..130
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..398
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..464
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 41..64
FT /evidence="ECO:0000250"
FT DISULFID 55..96
FT /evidence="ECO:0000250"
FT DISULFID 78..112
FT /evidence="ECO:0000250"
FT VAR_SEQ 325..365
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_002003"
FT CONFLICT 233
FT /note="S -> W (in Ref. 2; L07380)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="C -> S (in Ref. 2; L07380)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 464 AA; 51522 MW; 5FFF49A7D79A4114 CRC64;
MDSLLWATWV LCLLNLWGVA LGHLHLECDF ITQLRDDELA CLQAAEGTNN SSMGCPGTWD
GLLCWPPTGS GQWVSLPCPE FFSHFGSDPG AVKRDCTITG WSDPFPPYPV ACPVPLELLT
EEKSYFSTVK IIYTTGHSIS IVALCVAIAI LVALRRLHCP RNYIHTQLFA TFILKASAVF
LKDAAVFQGD STDHCSMSTI LCKVSVAVSH FATMTNFSWL LAEAVYLSCL LASTSPRSKP
AFWWLVLAGW GLPVLCTGTW VGCKLAFEDT ACWDLDDSSP YWWIIKGPIV LSVGVNFGLF
LNIICILLRK LGPAQGGLHT RAQYCNYLLP WSCPLPQVPR ERTDLGPSSH EITVQESGTR
NCQLPWRLSK STLLLIPLFG IHYIIFNFLP DSAGLGIRLP LELGLGSFQG FVVAVLYCFL
NQEVRTEISR KWYGHDPELL PARRTCTEWT TPPRSRVKVL TSEC
