GHSR_PIG
ID GHSR_PIG Reviewed; 366 AA.
AC Q95254; Q95255;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Growth hormone secretagogue receptor type 1;
DE Short=GHS-R;
DE AltName: Full=GH-releasing peptide receptor;
DE Short=GHRP;
DE AltName: Full=Ghrelin receptor;
GN Name=GHSR;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B).
RC STRAIN=Yorkshire; TISSUE=Pituitary;
RX PubMed=8688086; DOI=10.1126/science.273.5277.974;
RA Howard A.D., Feighner S.D., Cully D.F., Arena J.P., Liberator P.A.,
RA Rosenblum C.I., Hamelin M., Hreniuk D.L., Palyha O.C., Anderson J.,
RA Paress P.S., Diaz C., Chou M., Liu K.K., McKee K.K., Pong S.-S.,
RA Chaung L.-Y., Elbrecht A., Dashkevicz M., Heavens R., Rigby M.,
RA Sirinathsinghji D.J.S., Dean D.C., Melillo D.G., Patchett A.A., Nargund R.,
RA Griffin P.R., Demartino J.A., Gupta S.K., Schaeffer J.M., Smith R.G.,
RA van der Ploeg L.H.T.;
RT "A receptor in pituitary and hypothalamus that functions in growth hormone
RT release.";
RL Science 273:974-977(1996).
CC -!- FUNCTION: Receptor for ghrelin, coupled to G-alpha-11 proteins.
CC Stimulates growth hormone secretion. Binds also other growth hormone
CC releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as
CC non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-
CC 0677, adenosine).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1A;
CC IsoId=Q95254-1; Sequence=Displayed;
CC Name=1B;
CC IsoId=Q95254-2; Sequence=VSP_001918, VSP_001919;
CC -!- TISSUE SPECIFICITY: Pituitary and hypothalamus.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U60178; AAC48630.1; -; mRNA.
DR EMBL; U60180; AAC48631.1; -; mRNA.
DR RefSeq; NP_999345.1; NM_214180.1. [Q95254-1]
DR AlphaFoldDB; Q95254; -.
DR SMR; Q95254; -.
DR STRING; 9823.ENSSSCP00000012525; -.
DR BindingDB; Q95254; -.
DR ChEMBL; CHEMBL2224; -.
DR PaxDb; Q95254; -.
DR PRIDE; Q95254; -.
DR Ensembl; ENSSSCT00000012865; ENSSSCP00000012525; ENSSSCG00000020906. [Q95254-1]
DR Ensembl; ENSSSCT00015103407; ENSSSCP00015043090; ENSSSCG00015076501. [Q95254-1]
DR Ensembl; ENSSSCT00025089656; ENSSSCP00025039240; ENSSSCG00025065336. [Q95254-1]
DR Ensembl; ENSSSCT00030015905; ENSSSCP00030007123; ENSSSCG00030011593. [Q95254-1]
DR Ensembl; ENSSSCT00035016614; ENSSSCP00035005755; ENSSSCG00035013159. [Q95254-1]
DR Ensembl; ENSSSCT00040003967; ENSSSCP00040001235; ENSSSCG00040003174. [Q95254-1]
DR Ensembl; ENSSSCT00045058121; ENSSSCP00045040628; ENSSSCG00045033986. [Q95254-1]
DR Ensembl; ENSSSCT00050044816; ENSSSCP00050018415; ENSSSCG00050033428. [Q95254-1]
DR Ensembl; ENSSSCT00055028026; ENSSSCP00055022326; ENSSSCG00055014215. [Q95254-1]
DR Ensembl; ENSSSCT00060097610; ENSSSCP00060042315; ENSSSCG00060071407. [Q95254-1]
DR Ensembl; ENSSSCT00065060265; ENSSSCP00065026114; ENSSSCG00065044068. [Q95254-1]
DR Ensembl; ENSSSCT00070044601; ENSSSCP00070037580; ENSSSCG00070022444. [Q95254-1]
DR GeneID; 397372; -.
DR KEGG; ssc:397372; -.
DR CTD; 2693; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244813; -.
DR HOGENOM; CLU_962965_0_0_1; -.
DR InParanoid; Q95254; -.
DR OMA; MVWTSSI; -.
DR OrthoDB; 890529at2759; -.
DR TreeFam; TF332184; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Proteomes; UP000314985; Chromosome 13.
DR Bgee; ENSSSCG00000020906; Expressed in caecum and 42 other tissues.
DR ExpressionAtlas; Q95254; baseline and differential.
DR GO; GO:0009986; C:cell surface; IDA:HGNC-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:HGNC-UCL.
DR GO; GO:0001616; F:growth hormone secretagogue receptor activity; IDA:HGNC-UCL.
DR GO; GO:0016520; F:growth hormone-releasing hormone receptor activity; IDA:HGNC-UCL.
DR GO; GO:0008154; P:actin polymerization or depolymerization; ISS:UniProtKB.
DR GO; GO:0008343; P:adult feeding behavior; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0046697; P:decidualization; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:HGNC-UCL.
DR GO; GO:0030252; P:growth hormone secretion; IEA:Ensembl.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IDA:HGNC-UCL.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; ISS:UniProtKB.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:UniProtKB.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:UniProtKB.
DR GO; GO:0032100; P:positive regulation of appetite; IEA:Ensembl.
DR GO; GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; ISS:UniProtKB.
DR GO; GO:0051963; P:regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0032094; P:response to food; IEA:Ensembl.
DR GO; GO:0009725; P:response to hormone; ISS:UniProtKB.
DR InterPro; IPR039129; 7tmA_GHSR.
DR InterPro; IPR003905; GHS-R/MTLR.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24243:SF7; PTHR24243:SF7; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01417; GHSRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..366
FT /note="Growth hormone secretagogue receptor type 1"
FT /id="PRO_0000069481"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..285
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..326
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 116..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 266..289
FT /note="AVVVFAFILCWLPFHVGRYLFSKS -> GGSQCALELSLPGPLHSSCLFSSP
FT (in isoform 1B)"
FT /evidence="ECO:0000303|PubMed:8688086"
FT /id="VSP_001918"
FT VAR_SEQ 290..366
FT /note="Missing (in isoform 1B)"
FT /evidence="ECO:0000303|PubMed:8688086"
FT /id="VSP_001919"
SQ SEQUENCE 366 AA; 41195 MW; 2C850B3EF61B7C1C CRC64;
MWNATPSEEP GPNLTLPDLG WDAPPENDSL VEELLPLFPT PLLAGVTATC VALFVVGIAG
NLLTMLVVSR FREMRTTTNL YLSSMAFSDL LIFLCMPLDL FRLWQYRPWN LGNLLCKLFQ
FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVILVIWAV AFCSAGPIFV
LVGVEHDNGT DPRDTNECRA TEFAVRSGLL TVMVWVSSVF FFLPVFCLTV LYSLIGRKLW
RRKRGEAAVG SSLRDQNHKQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSL EPGSVEIAQI
SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFKLLGF EPFSQRKLST LKDESSRAWT
ESSINT
