GHSR_RABIT
ID GHSR_RABIT Reviewed; 366 AA.
AC A5A4K9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Growth hormone secretagogue receptor type 1;
DE Short=GHS-R;
DE AltName: Full=GH-releasing peptide receptor;
DE Short=GHRP;
DE AltName: Full=Ghrelin receptor;
GN Name=GHSR;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA van der Keyl H.K.;
RT "Ghrelin receptor orthologs.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for ghrelin, coupled to G-alpha-11 proteins.
CC Stimulates growth hormone secretion. Binds also other growth hormone
CC releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as
CC non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-
CC 0677, adenosine) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; EF526305; ABP88929.1; -; mRNA.
DR RefSeq; NP_001093438.1; NM_001099968.1.
DR AlphaFoldDB; A5A4K9; -.
DR SMR; A5A4K9; -.
DR STRING; 9986.ENSOCUP00000006345; -.
DR BindingDB; A5A4K9; -.
DR ChEMBL; CHEMBL5307; -.
DR Ensembl; ENSOCUT00000007339; ENSOCUP00000006345; ENSOCUG00000007340.
DR GeneID; 100101582; -.
DR KEGG; ocu:100101582; -.
DR CTD; 2693; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244813; -.
DR HOGENOM; CLU_009579_6_5_1; -.
DR InParanoid; A5A4K9; -.
DR OMA; MVWTSSI; -.
DR OrthoDB; 890529at2759; -.
DR TreeFam; TF332184; -.
DR PRO; PR:A5A4K9; -.
DR Proteomes; UP000001811; Chromosome 14.
DR Bgee; ENSOCUG00000007340; Expressed in frontal cortex and 1 other tissue.
DR ExpressionAtlas; A5A4K9; baseline.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001616; F:growth hormone secretagogue receptor activity; IEA:Ensembl.
DR GO; GO:0016520; F:growth hormone-releasing hormone receptor activity; IEA:Ensembl.
DR GO; GO:0008154; P:actin polymerization or depolymerization; IEA:Ensembl.
DR GO; GO:0008343; P:adult feeding behavior; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0046697; P:decidualization; IEA:Ensembl.
DR GO; GO:0030252; P:growth hormone secretion; IEA:Ensembl.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032100; P:positive regulation of appetite; IEA:Ensembl.
DR GO; GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0051963; P:regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0032094; P:response to food; IEA:Ensembl.
DR InterPro; IPR039129; 7tmA_GHSR.
DR InterPro; IPR003905; GHS-R/MTLR.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24243:SF7; PTHR24243:SF7; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01417; GHSRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..366
FT /note="Growth hormone secretagogue receptor type 1"
FT /id="PRO_0000310946"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..263
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..285
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..326
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 116..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 366 AA; 41132 MW; A884B4FBD5711B23 CRC64;
MWNATPSEEP GSNLTRAELG WDAPPGNDSL ADELLQLFPA PLLAGVTATC VALFVVGIAG
NLLTMLVVSR FRELRTTTNL YLSSMAFSDL LIFLCMPLDL VRLWQYRPWN FGDLLCKLFQ
FVSESCTYAT VLTITALSVE RYFAICFPLR AKVVVTKGRV KLVILVIWAL AFCSAGPIFV
LVGVEHENGT DPQDTNECRA TEFAVRSGLL TIMVWVSSVF FFLPVFCLTV LYSLIGRKLW
RRKRGDGAVG SSLRDQNHRQ TVKMLAVVVF AFILCWLPFH VGRYLFSKSF EPGSLEIAQI
SQYCNLVSFV LFYLSAAINP ILYNIMSKKY RVAVFKLLGF EPFSQRKLST LKDESSRAWT
KSSINT
