GH_BHV1C
ID GH_BHV1C Reviewed; 842 AA.
AC P27599;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Envelope glycoprotein H {ECO:0000255|HAMAP-Rule:MF_04033};
DE Short=gH {ECO:0000255|HAMAP-Rule:MF_04033};
DE Flags: Precursor;
GN Name=gH {ECO:0000255|HAMAP-Rule:MF_04033}; ORFNames=UL22;
OS Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine
OS rhinotracheitis virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10323;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1657187; DOI=10.1016/0167-4781(91)90116-4;
RA Meyer A.L., Petrovskis E.A., Duffus W.P., Thomsen D.R., Post L.E.;
RT "Cloning and sequence of an infectious bovine rhinotracheitis virus (BHV-1)
RT gene homologous to glycoprotein H of herpes simplex virus.";
RL Biochim. Biophys. Acta 1090:267-269(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Schwyzer M., Paces V., Letchworth G.J., Misra V., Buhk H.J., Lowery D.E.,
RA Simard C., Bello L.J., Thiry E., Vlcek C.;
RT "Complete DNA sequence of bovine herpesvirus 1.";
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is required for
CC the fusion of viral and plasma membranes leading to virus entry into
CC the host cell. Following initial binding to host receptor, membrane
CC fusion is mediated by the fusion machinery composed of gB and the
CC heterodimer gH/gL. May also be involved in the fusion between the
CC virion envelope and the outer nuclear membrane during virion
CC morphogenesis. {ECO:0000255|HAMAP-Rule:MF_04033}.
CC -!- SUBUNIT: Interacts with glycoprotein L (gL); this interaction is
CC necessary for the correct processing and cell surface expression of gH.
CC The heterodimer gH/gL seems to interact with gB trimers during fusion.
CC {ECO:0000255|HAMAP-Rule:MF_04033}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC Rule:MF_04033}; Single-pass type I membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04033}. Host cell membrane {ECO:0000255|HAMAP-Rule:MF_04033};
CC Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04033}.
CC Host endosome membrane {ECO:0000255|HAMAP-Rule:MF_04033}; Single-pass
CC type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04033}. Note=During
CC virion morphogenesis, this protein probably accumulates in the
CC endosomes and trans-Golgi where secondary envelopment occurs. It is
CC probably transported to the cell surface from where it is endocytosed
CC and directed to the trans-Golgi network (TGN). {ECO:0000255|HAMAP-
CC Rule:MF_04033}.
CC -!- PTM: N-glycosylated, O-glycosylated, and sialylated.
CC {ECO:0000255|HAMAP-Rule:MF_04033}.
CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein H family.
CC {ECO:0000255|HAMAP-Rule:MF_04033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X58867; CAA41677.1; -; Genomic_DNA.
DR EMBL; Z78205; CAB01604.1; -; Genomic_DNA.
DR EMBL; AJ004801; CAA06112.1; -; Genomic_DNA.
DR PIR; S18462; S18462.
DR RefSeq; NP_045337.1; NC_001847.1.
DR SMR; P27599; -.
DR PRIDE; P27599; -.
DR GeneID; 4783417; -.
DR KEGG; vg:4783417; -.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0016032; P:viral process; IMP:AgBase.
DR Gene3D; 2.60.40.3190; -; 1.
DR HAMAP; MF_04033; HSV_GH; 1.
DR InterPro; IPR003493; Herpes_gH.
DR InterPro; IPR035305; Herpes_glycoH_C.
DR InterPro; IPR038172; Herpes_glycoH_C_sf.
DR Pfam; PF17488; Herpes_glycoH_C; 1.
PE 3: Inferred from homology;
KW Fusion of virus membrane with host cell membrane;
KW Fusion of virus membrane with host membrane; Glycoprotein;
KW Host cell membrane; Host endosome; Host membrane; Membrane; Sialic acid;
KW Signal; Transmembrane; Transmembrane helix; Viral envelope protein;
KW Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT SIGNAL 1..20
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT CHAIN 21..842
FT /note="Envelope glycoprotein H"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT /id="PRO_0000436647"
FT TOPO_DOM 21..802
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT TRANSMEM 803..823
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT TOPO_DOM 824..842
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT REGION 240..303
FT /note="Interaction with gL"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT CARBOHYD 617
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT CARBOHYD 666
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT CARBOHYD 760
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
FT CARBOHYD 783
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04033"
SQ SEQUENCE 842 AA; 88375 MW; BA90759A74715F98 CRC64;
MRRPLCAALL AAAVLALAAG APAAARGGAG GRSREHRDAR YEIEEWEMVV GAGPAVHTFT
IRCLGPRGIE RVAHIANLSR LLDGYIAVHV DVARTSGLRD TMFFLPRAAV DNASAADIPD
TPAVQSHPGL FGAAFSWSYL QTRHLVDYDL VPSRPLQDWY FSQARAESNA ARPPPAPRVT
PTPAGRVAAF DINDVLASGP EHFFVPVRAD RKRRERHVAD FAAVWPVSYI PAGRAVLSCE
RAAARLAVGL GFLSVSVTSR DLLPLEFMVA PADANVRMIT AFNGGGAFPP PGPAAGPQRR
AYVIGYGNSR LDSHMYLTMR EVASYANEPA DFRAHLTAAH REAFLMLREA AAARRGPSAG
PAPNAAYHAY RVAARLGLAL SALTEGALAD GYVLAEELVD LDYHLKLLSR VLLGAGLGCA
ANGRVRARTI AQLAVPRELR PDAFIPEPAG AALESVVARG RKLRAVYAFS GPDAPLAARL
LAHGVVSDLY DAFLRGELTW GPPMRHALFF AVAASAFPAD AQALELARDV TRKCTAMCTA
GHATAAALDL EEVYAHVGGG AGGDAGFELL DAFSPCMASF RLDLLEEAHV LDVLSAVPAR
AALDAWLEAQ PAAAAPNLSA AALGMLGRGG LFGPAHAAAL APELFAAPCG GWGAGAAVAI
VPVAPNASYV ITRAHPRRGL TYTLQGIDVA NPLLVTFVRG TSCVSASGAV EARRLAVPGP
LDACAYCGSV FVRYLPSGAV MDIVLIADKR TEVEFSRGAN SSMPVFNPRL HSGRSRAMLL
FPNGTVVSVL AFAGHEAPTF SPAYVWASVG GALVAGTTIY AIAKMLCSSV PLARGYSSVP
VF
