ID   GIA2_GIAIN              Reviewed;         296 AA.
AC   P19389;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Giardin subunit alpha-2;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Portland-1;
RX   PubMed=1542319; DOI=10.1016/0166-6851(92)90247-h;
RA   Alonso R.A., Peattie D.A.;
RT   "Nucleotide sequence of a second alpha giardin gene and molecular analysis
RT   of the alpha giardin genes and transcripts in Giardia lamblia.";
RL   Mol. Biochem. Parasitol. 50:95-104(1992).
CC   -!- FUNCTION: Giardins are involved in parasite attachment to the
CC       intestinal mucosa and in the cytoskeletal disassembly and reassembly
CC       that marks the transition from infectious trophozoite to transmissible
CC       cyst. They may interact with other cytoskeletal proteins such as
CC       microtubules in the microribbons or crossbridges, to maintain the
CC       integrity of the ventral disk.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Most likely in the
CC       edges of the ventral disk microribbons.
CC   -!- SIMILARITY: Belongs to the annexin family. Giardin subunit alpha
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01245}.
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DR   EMBL; M34550; AAA29150.1; -; Genomic_DNA.
DR   PIR; A45645; A45645.
DR   RefSeq; XP_001706958.1; XM_001706906.1.
DR   AlphaFoldDB; P19389; -.
DR   SMR; P19389; -.
DR   PRIDE; P19389; -.
DR   GeneID; 5699853; -.
DR   KEGG; gla:GL50803_007796; -.
DR   VEuPathDB; GiardiaDB:DHA2_7796; -.
DR   VEuPathDB; GiardiaDB:GL50581_1672; -.
DR   VEuPathDB; GiardiaDB:GL50803_007796; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR008088; Alpha_giardin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR037104; Annexin_sf.
DR   Pfam; PF00191; Annexin; 1.
DR   PRINTS; PR01712; ALPHAGIARDIN.
DR   SMART; SM00335; ANX; 1.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   3: Inferred from homology;
KW   Annexin; Cytoplasm; Cytoskeleton; Microtubule; Repeat.
FT   CHAIN           1..296
FT                   /note="Giardin subunit alpha-2"
FT                   /id="PRO_0000067523"
FT   REPEAT          2..71
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          73..143
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          153..223
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          226..293
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
SQ   SEQUENCE   296 AA;  33936 MW;  AA9C79312C716A54 CRC64;
     MPKLSQIVAD MKQAIDAKDE AQIAFIASEY SADARQRIAQ GYRDQYGKEL PDDIKKALKG
     GSEESLLMDL FSDRHEVRAQ HIRDALSGKN DHMAFFDTVI LCTPEDWHET VAAYTRMFKK
     PLVEDFMKDV GRKENWCLFM EKWMAHERTS REGSPDEEAE KLNKAFSESD HDYISSFMAG
     VPPEEYKSIN TSFKSLTGKG IDQAFATIYT GTDYYSLYCA HFALLGMHKL AAYLVNCACN
     DKGDEKRMRR ITGMMVDKCL AAKYAYKTYG SMKADVERCF DKRMAPILCT LWRLRE