ID   GIA3_GIAIN              Reviewed;         296 AA.
AC   Q4VPP7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Giardin subunit alpha-3;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB-C6;
RX   PubMed=15862575; DOI=10.1016/j.ijpara.2004.12.009;
RA   Weiland M.E.-L., McArthur A.G., Morrison H.G., Sogin M.L., Svard S.G.;
RT   "Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia
RT   lamblia.";
RL   Int. J. Parasitol. 35:617-626(2005).
CC   -!- FUNCTION: Giardins are involved in parasite attachment to the
CC       intestinal mucosa and in the cytoskeletal disassembly and reassembly
CC       that marks the transition from infectious trophozoite to transmissible
CC       cyst. They may interact with other cytoskeletal proteins such as
CC       microtubules in the microribbons or crossbridges, to maintain the
CC       integrity of the ventral disk (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the annexin family. Giardin subunit alpha
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01245}.
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DR   EMBL; AY781325; AAX07976.1; -; Genomic_DNA.
DR   RefSeq; XP_001708837.1; XM_001708785.1.
DR   AlphaFoldDB; Q4VPP7; -.
DR   SMR; Q4VPP7; -.
DR   PRIDE; Q4VPP7; -.
DR   GeneID; 5701751; -.
DR   KEGG; gla:GL50803_0011683; -.
DR   VEuPathDB; GiardiaDB:DHA2_11683; -.
DR   VEuPathDB; GiardiaDB:GL50581_4264; -.
DR   VEuPathDB; GiardiaDB:GL50803_0011683; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR008088; Alpha_giardin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR037104; Annexin_sf.
DR   PRINTS; PR01712; ALPHAGIARDIN.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   3: Inferred from homology;
KW   Annexin; Cytoplasm; Cytoskeleton; Microtubule; Repeat.
FT   CHAIN           1..296
FT                   /note="Giardin subunit alpha-3"
FT                   /id="PRO_0000288026"
FT   REPEAT          3..72
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          74..146
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          153..222
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          226..295
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
SQ   SEQUENCE   296 AA;  33320 MW;  77A2A3B343484CEF CRC64;
     MSDTVTKVVA DLNAAILQKS ARAIAEVACK YSASDREKVR AQYRSTYSIE PDDHINKMLK
     GGDAATIVSN CWDELPVLRA KHLSKALKGS VDHRALLDLL IMCDREDWNN TVVAFTQQFR
     KNLPEELEKA LKSTTSYRAF YTTWIKFDRA PRNNINGDAL KLKEAFSKKD EQTVFDIMST
     TVESEYKAIA TQFEKVAGMT MIQAFAALTS GPLYWALHTA HYRNIGMNNG AAFLIHHACT
     ADKKGDIARM TRLSPLLCDK CLNAKNYYSE FGDMGKDIVN AFKDAVEEVL KVLWRV