ID   GIA4_GIAIN              Reviewed;         296 AA.
AC   Q4VPQ3;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Giardin subunit alpha-4;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB-C6;
RX   PubMed=15862575; DOI=10.1016/j.ijpara.2004.12.009;
RA   Weiland M.E.-L., McArthur A.G., Morrison H.G., Sogin M.L., Svard S.G.;
RT   "Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia
RT   lamblia.";
RL   Int. J. Parasitol. 35:617-626(2005).
CC   -!- FUNCTION: Giardins are involved in parasite attachment to the
CC       intestinal mucosa and in the cytoskeletal disassembly and reassembly
CC       that marks the transition from infectious trophozoite to transmissible
CC       cyst. They may interact with other cytoskeletal proteins such as
CC       microtubules in the microribbons or crossbridges, to maintain the
CC       integrity of the ventral disk (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the annexin family. Giardin subunit alpha
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01245}.
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DR   EMBL; AY781319; AAX07970.1; -; Genomic_DNA.
DR   RefSeq; XP_001706962.1; XM_001706910.1.
DR   AlphaFoldDB; Q4VPQ3; -.
DR   SMR; Q4VPQ3; -.
DR   PRIDE; Q4VPQ3; -.
DR   GeneID; 5699857; -.
DR   KEGG; gla:GL50803_007799; -.
DR   VEuPathDB; GiardiaDB:DHA2_7799; -.
DR   VEuPathDB; GiardiaDB:GL50581_1669; -.
DR   VEuPathDB; GiardiaDB:GL50803_007799; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR008088; Alpha_giardin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR037104; Annexin_sf.
DR   PRINTS; PR01712; ALPHAGIARDIN.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   3: Inferred from homology;
KW   Annexin; Cytoplasm; Cytoskeleton; Microtubule; Repeat.
FT   CHAIN           1..296
FT                   /note="Giardin subunit alpha-4"
FT                   /id="PRO_0000288027"
FT   REPEAT          3..72
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          74..146
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          153..223
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          226..294
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
SQ   SEQUENCE   296 AA;  33614 MW;  E8E15BDE4A1CC5A9 CRC64;
     MSATVSTVSA DLHKAIDAGD EDKITKITAS YGSEQRDKII PAYHANYGIP PSEAIRKAFK
     TGFYETMIVH AWTSRFELRA KLIHESIKGK IDVITLLDLV IACMPDDWYG TKVCYTKLYG
     RELVREIDEV IGVGTPWQSL VSGWVKHDRK YRKSIKSDAE AFRMALDSDN YEVLGSMLAT
     SVPDEWMRIA AAYEETTGMP IDQAIASRYV KVDQTALILA HHWLCDPGQA AAYICSQCCA
     ERKGNYARIC RFTSMMYDHC LKCKYAYRAY GSLAMDIRKC FEPKLAKHLL VFWRVE