ID   GIA5_GIAIN              Reviewed;         302 AA.
AC   Q4VPQ4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Giardin subunit alpha-5;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB-C6;
RX   PubMed=15862575; DOI=10.1016/j.ijpara.2004.12.009;
RA   Weiland M.E.-L., McArthur A.G., Morrison H.G., Sogin M.L., Svard S.G.;
RT   "Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia
RT   lamblia.";
RL   Int. J. Parasitol. 35:617-626(2005).
CC   -!- FUNCTION: Giardins are involved in parasite attachment to the
CC       intestinal mucosa and in the cytoskeletal disassembly and reassembly
CC       that marks the transition from infectious trophozoite to transmissible
CC       cyst. They may interact with other cytoskeletal proteins such as
CC       microtubules in the microribbons or crossbridges, to maintain the
CC       integrity of the ventral disk (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the annexin family. Giardin subunit alpha
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01245}.
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DR   EMBL; AY781318; AAX07969.1; -; Genomic_DNA.
DR   RefSeq; XP_001706959.1; XM_001706907.1.
DR   AlphaFoldDB; Q4VPQ4; -.
DR   SMR; Q4VPQ4; -.
DR   PRIDE; Q4VPQ4; -.
DR   GeneID; 5699854; -.
DR   KEGG; gla:GL50803_007797; -.
DR   VEuPathDB; GiardiaDB:DHA2_7797; -.
DR   VEuPathDB; GiardiaDB:GL50581_1671; -.
DR   VEuPathDB; GiardiaDB:GL50803_007797; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR008088; Alpha_giardin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR037104; Annexin_sf.
DR   Pfam; PF00191; Annexin; 1.
DR   PRINTS; PR01712; ALPHAGIARDIN.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   3: Inferred from homology;
KW   Annexin; Cytoplasm; Cytoskeleton; Microtubule; Repeat.
FT   CHAIN           1..302
FT                   /note="Giardin subunit alpha-5"
FT                   /id="PRO_0000288028"
FT   REPEAT          1..72
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          74..144
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          153..226
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          230..298
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
SQ   SEQUENCE   302 AA;  33921 MW;  8138A25161A194D5 CRC64;
     MTSTVAQICS DLKGAIDKKD ELRIAFIASE YSSPSRLKIA QSYEATYKTP ITEAIKKSLK
     GGTAEDLLVN MWVSRHEHRA ELINKALGGS SDEEAIRELV FLCNPEDWHE TASVYNQKYQ
     KIMQDAVTKA IGSKSHWAKL VAGWMEHKRE DRGSVENDVK YLKELIDAPV TDGNALAQFF
     ASTTPDEYTQ IADKFCEEYN LSIDQALVRP LKENEDDLEA YAAAHFALHG LPVLAAQLIN
     KACRPKNGNE RSICRITTLM VDQCLAAKYA YKLYGDMGAD LSRCFDERMA PILRTLWRVT
     DA