ID   GIA6_GIAIN              Reviewed;         297 AA.
AC   Q4VPP5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Giardin subunit alpha-6;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB-C6;
RX   PubMed=15862575; DOI=10.1016/j.ijpara.2004.12.009;
RA   Weiland M.E.-L., McArthur A.G., Morrison H.G., Sogin M.L., Svard S.G.;
RT   "Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia
RT   lamblia.";
RL   Int. J. Parasitol. 35:617-626(2005).
CC   -!- FUNCTION: Giardins are involved in parasite attachment to the
CC       intestinal mucosa and in the cytoskeletal disassembly and reassembly
CC       that marks the transition from infectious trophozoite to transmissible
CC       cyst. They may interact with other cytoskeletal proteins such as
CC       microtubules in the microribbons or crossbridges, to maintain the
CC       integrity of the ventral disk (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the annexin family. Giardin subunit alpha
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01245}.
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DR   EMBL; AY781327; AAX07978.1; -; Genomic_DNA.
DR   RefSeq; XP_001706961.1; XM_001706909.1.
DR   AlphaFoldDB; Q4VPP5; -.
DR   SMR; Q4VPP5; -.
DR   PRIDE; Q4VPP5; -.
DR   GeneID; 5699856; -.
DR   KEGG; gla:GL50803_0014551; -.
DR   VEuPathDB; GiardiaDB:DHA2_14551; -.
DR   VEuPathDB; GiardiaDB:GL50581_1670; -.
DR   VEuPathDB; GiardiaDB:GL50803_0014551; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR008088; Alpha_giardin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR037104; Annexin_sf.
DR   PRINTS; PR01712; ALPHAGIARDIN.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   3: Inferred from homology;
KW   Annexin; Cytoplasm; Cytoskeleton; Microtubule; Repeat.
FT   CHAIN           1..297
FT                   /note="Giardin subunit alpha-6"
FT                   /id="PRO_0000288029"
FT   REPEAT          3..72
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          74..146
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          153..222
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          226..295
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
SQ   SEQUENCE   297 AA;  33148 MW;  241D45862C1F9BB2 CRC64;
     MVTTVQDLAE QLRQAVESSN EQMIAGLASA YSGKEREKVL RAYLSATGTT AADAIRKALK
     NGPTENLLAY LWDKPGDVRA KLIRNALSGK NDEAALIDLV IHCSSEDWYN TCTEYTTDYK
     RVLNDDLLSD IGTKEQWTKV FKHWILHKRS DRFDIDGDEK RLVTAIGKKD YDTIAEMLGT
     TSVSEYANIV RRAEVTLGKT IDQALSAVWS KQDLAVLLAA HYELLHPARL AFHLLKQALD
     GKKPDEARII RITALTFDTC LAVKYAASEA GYDIGSAFAK ALDKRLAPLI KILWRVM