ID   GIA8_GIAIN              Reviewed;         311 AA.
AC   Q4VPP9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Giardin subunit alpha-8;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB-C6;
RX   PubMed=15862575; DOI=10.1016/j.ijpara.2004.12.009;
RA   Weiland M.E.-L., McArthur A.G., Morrison H.G., Sogin M.L., Svard S.G.;
RT   "Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia
RT   lamblia.";
RL   Int. J. Parasitol. 35:617-626(2005).
CC   -!- FUNCTION: Giardins are involved in parasite attachment to the
CC       intestinal mucosa and in the cytoskeletal disassembly and reassembly
CC       that marks the transition from infectious trophozoite to transmissible
CC       cyst. They may interact with other cytoskeletal proteins such as
CC       microtubules in the microribbons or crossbridges, to maintain the
CC       integrity of the ventral disk (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the annexin family. Giardin subunit alpha
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01245}.
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DR   EMBL; AY781323; AAX07974.1; -; Genomic_DNA.
DR   RefSeq; XP_001704306.1; XM_001704254.1.
DR   AlphaFoldDB; Q4VPP9; -.
DR   SMR; Q4VPP9; -.
DR   PRIDE; Q4VPP9; -.
DR   GeneID; 5697158; -.
DR   KEGG; gla:GL50803_0011649; -.
DR   VEuPathDB; GiardiaDB:DHA2_11649; -.
DR   VEuPathDB; GiardiaDB:GL50581_2211; -.
DR   VEuPathDB; GiardiaDB:GL50803_0011649; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR008088; Alpha_giardin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR037104; Annexin_sf.
DR   Pfam; PF00191; Annexin; 1.
DR   PRINTS; PR01712; ALPHAGIARDIN.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   3: Inferred from homology;
KW   Annexin; Cytoplasm; Cytoskeleton; Microtubule; Repeat.
FT   CHAIN           1..311
FT                   /note="Giardin subunit alpha-8"
FT                   /id="PRO_0000288030"
FT   REPEAT          5..73
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          75..146
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          154..223
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          227..295
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
SQ   SEQUENCE   311 AA;  35769 MW;  F71D5EE17570F426 CRC64;
     MDDSRKAYVV AQDLHNAIMQ RDAITISEIT GRYVSGYREK IALAFMEQYN VLPADLFKEW
     GTGYFESLMI RCWTNRHEAR AKMLKEAIRG ALDRDALVDL VILCSTDDWA STLVHYQKHF
     RIALKADIRL NMPADRPWKA LIDRWMEHDR HYRNNVKTDA HMLLQALEGG NGAAIVDILV
     TTKPQEWEKI VAAYEEHTNK SLETAICMAF PGFEQTAFCA AHYWLCEPSK AAAFLIHRAC
     EGKRGDFRRV CRITSLVLDQ CLKCKYVYSV YGHLAADFRK TFSDNTAIPL ISLWRAYDIG
     KILAEKHENI T