ID   GIA9_GIAIN              Reviewed;         301 AA.
AC   Q4VPP0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Giardin subunit alpha-9;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB-C6;
RX   PubMed=15862575; DOI=10.1016/j.ijpara.2004.12.009;
RA   Weiland M.E.-L., McArthur A.G., Morrison H.G., Sogin M.L., Svard S.G.;
RT   "Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia
RT   lamblia.";
RL   Int. J. Parasitol. 35:617-626(2005).
CC   -!- FUNCTION: Giardins are involved in parasite attachment to the
CC       intestinal mucosa and in the cytoskeletal disassembly and reassembly
CC       that marks the transition from infectious trophozoite to transmissible
CC       cyst. They may interact with other cytoskeletal proteins such as
CC       microtubules in the microribbons or crossbridges, to maintain the
CC       integrity of the ventral disk (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the annexin family. Giardin subunit alpha
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01245}.
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DR   EMBL; AY781332; AAX07983.1; -; Genomic_DNA.
DR   RefSeq; XP_001704289.1; XM_001704237.1.
DR   AlphaFoldDB; Q4VPP0; -.
DR   SMR; Q4VPP0; -.
DR   PRIDE; Q4VPP0; -.
DR   GeneID; 5697160; -.
DR   KEGG; gla:GL50803_00103437; -.
DR   VEuPathDB; GiardiaDB:DHA2_103437; -.
DR   VEuPathDB; GiardiaDB:GL50581_2198; -.
DR   VEuPathDB; GiardiaDB:GL50803_00103437; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:InterPro.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.10.220.10; -; 4.
DR   InterPro; IPR008088; Alpha_giardin.
DR   InterPro; IPR018502; Annexin_repeat.
DR   InterPro; IPR037104; Annexin_sf.
DR   PRINTS; PR01712; ALPHAGIARDIN.
DR   SUPFAM; SSF47874; SSF47874; 1.
DR   PROSITE; PS51897; ANNEXIN_2; 4.
PE   3: Inferred from homology;
KW   Annexin; Cytoplasm; Cytoskeleton; Microtubule; Repeat.
FT   CHAIN           1..301
FT                   /note="Giardin subunit alpha-9"
FT                   /id="PRO_0000288031"
FT   REPEAT          2..72
FT                   /note="Annexin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          74..146
FT                   /note="Annexin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          153..223
FT                   /note="Annexin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
FT   REPEAT          225..294
FT                   /note="Annexin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01245"
SQ   SEQUENCE   301 AA;  33787 MW;  FD82C39C55586D17 CRC64;
     MSLTVSDLTT ELKKIIDSKN ESALVQLTSQ YASKHRDKVV INYKSIYGMY PADAIKKALK
     SGPAETLLMY AWTDAQEVRA RLLNQALSGK NNKSALIDVV LFCGPEDWYE MGAHYTRIFQ
     KVANDTLLSD IGSSEPWSQL IKGWIKHDRY ERKAISEDAA ALMGYLESGN PDGLIDLLCN
     TTEGEWKKIN KVFTEKYGVE VETLIASNYV KTDMEALLTA HFYLLQPGYA AAYLCSLANS
     GKKGDSDRMV RITSLMFDKA LKCKFAYEKY GKLGSDFKRL YDARLGRALC ALWRVDTEGA
     N