ID   GIAG_GIAIN              Reviewed;         311 AA.
AC   P38413;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Giardin subunit gamma;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 145-156.
RC   STRAIN=Portland-1;
RX   PubMed=1474999; DOI=10.1016/0166-6851(92)90151-9;
RA   Nohria A., Alonso R.A., Peattie D.A.;
RT   "Identification and characterization of gamma-giardin and the gamma-giardin
RT   gene from Giardia lamblia.";
RL   Mol. Biochem. Parasitol. 56:27-37(1992).
CC   -!- FUNCTION: Giardins are involved in parasite attachment to the
CC       intestinal mucosa and in the cytoskeletal disassembly and reassembly
CC       that marks the transition from infectious trophozoite to transmissible
CC       cyst. They may interact with other cytoskeletal proteins such as
CC       microtubules in the microribbons or crossbridges, to maintain the
CC       integrity of the ventral disk.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Microribbons of
CC       ventral disc.
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DR   EMBL; X55287; CAA39002.1; -; Genomic_DNA.
DR   PIR; A48453; S25163.
DR   RefSeq; XP_001706274.1; XM_001706222.1.
DR   AlphaFoldDB; P38413; -.
DR   SMR; P38413; -.
DR   PRIDE; P38413; -.
DR   GeneID; 5699172; -.
DR   KEGG; gla:GL50803_0017230; -.
DR   VEuPathDB; GiardiaDB:GL50581_4532; -.
DR   VEuPathDB; GiardiaDB:GL50803_0017230; -.
DR   OMA; SEHFGDX; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Direct protein sequencing;
KW   Microtubule.
FT   CHAIN           1..311
FT                   /note="Giardin subunit gamma"
FT                   /id="PRO_0000087485"
FT   COILED          185..233
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   311 AA;  35632 MW;  9651C4339C6BB17C CRC64;
     MKSSFSTVSS YSDHKFAVKD APTTIRDSLR LTNAVEDPGY MTLSLISENK VDDLMFNSKM
     FQDHMVNDFR PKFSHADSSE IMITLNNLKN DILSTKNIRE LESTDLRSEV AKQFAARRAE
     LVSHLNASLR PLIDEVFSME QRLKAFDAEN ADFVGKTKQY KSTFRSEVHS RIRAGQSKLD
     ALRHGLQTEI NSLEAIIERE FAQAANRLNQ EVSNFKESFD ASERNIKLQK KHVISGMNEK
     IKSFAESVAK YLPILKKNSE ERRFNQMMMQ KNLAEIMTVL SDNSEHFGDY CFSDLVPDTR
     IFDAIMTTKV D