GID2_ORYSJ
ID GID2_ORYSJ Reviewed; 212 AA.
AC Q7XAK4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=F-box protein GID2;
DE AltName: Full=Gibberellin-insensitive dwarf protein 2;
DE AltName: Full=Protein GIBBERELLIN INSENSITIVE DWARF2;
GN Name=GID2; OrderedLocusNames=Os02g0580300, LOC_Os02g36974;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, COMPONENT OF A
RP SCF COMPLEX, AND INTERACTION WITH SLR1 AND SKP2.
RX PubMed=12649483; DOI=10.1126/science.1081077;
RA Sasaki A., Itoh H., Gomi K., Ueguchi-Tanaka M., Ishiyama K., Kobayashi M.,
RA Jeong D.-H., An G., Kitano H., Ashikari M., Matsuoka M.;
RT "Accumulation of phosphorylated repressor for gibberellin signaling in an
RT F-box mutant.";
RL Science 299:1896-1898(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH
RP CUL1; SKP15 AND SLR1.
RX PubMed=14756772; DOI=10.1111/j.1365-313x.2003.01990.x;
RA Gomi K., Sasaki A., Itoh H., Ueguchi-Tanaka M., Ashikari M., Kitano H.,
RA Matsuoka M.;
RT "GID2, an F-box subunit of the SCF E3 complex, specifically interacts with
RT phosphorylated SLR1 protein and regulates the gibberellin-dependent
RT degradation of SLR1 in rice.";
RL Plant J. 37:626-634(2004).
CC -!- FUNCTION: Essential component of some SCF-type E3 ligase complex that
CC positively regulates the gibberellin signaling pathway. Upon
CC gibberellin treatment, the complex mediates the ubiquitination and
CC subsequent degradation of DELLA protein SLR1, a repressor of the
CC gibberellin pathway, leading to activate the pathway.
CC {ECO:0000269|PubMed:12649483, ECO:0000269|PubMed:14756772}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of some SCF(GID2) complex, which consist of a SKP1
CC protein, CUL1, GID2 and some RING box protein. Interacts directly with
CC SKP2 and SKP15. Interacts directly with DELLA protein SLR1. May have a
CC higher affinity for phosphorylated SLR1 proteins.
CC {ECO:0000269|PubMed:12649483, ECO:0000269|PubMed:14756772}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12649483,
CC ECO:0000269|PubMed:14756772}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Preferentially expressed in
CC unopened flowers, shoot apices and elongation stem. Expressed at lower
CC level in the leaf blades, leaf sheaths, roots and rachis.
CC {ECO:0000269|PubMed:14756772}.
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DR EMBL; AB100246; BAC81428.1; -; mRNA.
DR EMBL; AP003999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP014958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q7XAK4; -.
DR STRING; 39947.Q7XAK4; -.
DR PRIDE; Q7XAK4; -.
DR EnsemblPlants; Os02t0580300-04; Os02t0580300-04; Os02g0580300.
DR Gramene; Os02t0580300-04; Os02t0580300-04; Os02g0580300.
DR PlantReactome; R-OSA-5679411; Gibberellin signaling.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR ExpressionAtlas; Q7XAK4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:Gramene.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IDA:Gramene.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IMP:Gramene.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0010265; P:SCF complex assembly; IDA:Gramene.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:Gramene.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR045118; FBXO9/FBXO48.
DR PANTHER; PTHR12874; PTHR12874; 1.
DR Pfam; PF00646; F-box; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 1: Evidence at protein level;
KW Gibberellin signaling pathway; Nucleus; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..212
FT /note="F-box protein GID2"
FT /id="PRO_0000119963"
FT DOMAIN 70..116
FT /note="F-box"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 212 AA; 23051 MW; E2378AC80F802B20 CRC64;
MKFRSDSSGG DEPRAPAAGD GGGGGDEPAK RQRTDPSSSS SQGEASSSSQ PPPQQQQEEQ
PPEDAGEGEQ PRVPDLGEDL VFEVLRRAEA RTLAAAACVS RGWRQLAEDE RLWEAACVRE
WANLGFSERQ LRAVVLSLGG FRRLHAVYIR PLQWRGAGVP RQQGRRQPPV RLGRDQVQLS
LSLFSIGFFQ NMPCPKKDKG NDSDKNGGGQ CG
