ID   GIG1_CANAL              Reviewed;         254 AA.
AC   Q59VM7; A0A1D8PD91;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=N-acetylglucosamine-induced protein 1 {ECO:0000303|PubMed:20675577};
DE            Short=GlcNAc-Induced Gene {ECO:0000303|PubMed:20675577};
GN   Name=GIG1 {ECO:0000303|PubMed:20675577};
GN   OrderedLocusNames=CAALFM_C104310CA; ORFNames=CaO19.1066, CaO19.8668;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   INDUCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=20675577; DOI=10.1128/ec.00178-10;
RA   Gunasekera A., Alvarez F.J., Douglas L.M., Wang H.X., Rosebrock A.P.,
RA   Konopka J.B.;
RT   "Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed
RT   for normal sensitivity to the chitin synthase inhibitor nikkomycin Z.";
RL   Eukaryot. Cell 9:1476-1483(2010).
RN   [5]
RP   INDUCTION.
RX   PubMed=21700702; DOI=10.1074/jbc.m111.249854;
RA   Naseem S., Gunasekera A., Araya E., Konopka J.B.;
RT   "N-acetylglucosamine (GlcNAc) induction of hyphal morphogenesis and
RT   transcriptional responses in Candida albicans are not dependent on its
RT   metabolism.";
RL   J. Biol. Chem. 286:28671-28680(2011).
CC   -!- FUNCTION: N-acetylglucosamine-induced protein which plays a role in the
CC       N-acetylglucosamine metabolic pathway. {ECO:0000269|PubMed:20675577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20675577}.
CC   -!- INDUCTION: Expression is induced by N-acetylglucosamine (GlcNAc).
CC       {ECO:0000269|PubMed:20675577, ECO:0000269|PubMed:21700702}.
CC   -!- DISRUPTION PHENOTYPE: Leads to increased resistance to the chitin
CC       synthase inhibitor nikkomycin Z. {ECO:0000269|PubMed:20675577}.
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DR   EMBL; CP017623; AOW26105.1; -; Genomic_DNA.
DR   RefSeq; XP_713670.1; XM_708577.1.
DR   AlphaFoldDB; Q59VM7; -.
DR   SMR; Q59VM7; -.
DR   STRING; 237561.Q59VM7; -.
DR   PRIDE; Q59VM7; -.
DR   GeneID; 3644712; -.
DR   KEGG; cal:CAALFM_C104310CA; -.
DR   CGD; CAL0000193934; GIG1.
DR   VEuPathDB; FungiDB:C1_04310C_A; -.
DR   eggNOG; ENOG502S263; Eukaryota.
DR   HOGENOM; CLU_075862_2_0_1; -.
DR   InParanoid; Q59VM7; -.
DR   OrthoDB; 1428152at2759; -.
DR   PRO; PR:Q59VM7; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IDA:CGD.
DR   GO; GO:0006044; P:N-acetylglucosamine metabolic process; IMP:CGD.
DR   InterPro; IPR022036; DUF3605.
DR   PANTHER; PTHR35020; PTHR35020; 1.
DR   Pfam; PF12239; DUF3605; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..254
FT                   /note="N-acetylglucosamine-induced protein 1"
FT                   /id="PRO_0000431723"
SQ   SEQUENCE   254 AA;  30127 MW;  5A3020A71941EC2F CRC64;
     MNPATIITNF NNSQLQTPPT SPVSFDKYYT YYNIQLEQST LMPQPSKIKN GDPFTWSDIQ
     FIIKSNQLEI FARSRQQTIK YHKFKQWLKD NKLSINDYLL DYELHWKESE LREQQHELVS
     DKEYSIDYPE DLIFHNPNDI SILYNKFPYY FEPNVKHICI WSKLKIPVDK NSEVGDISVM
     TKKLINRYLE KTFVAKGISW DQIVWFKNWL SLQSVRSISH IHVILKDVDD KFVDELISGG
     SGEVLTLDDY RNLE