ID   GIGA6_CRAGI             Reviewed;         302 AA.
AC   P86789;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Gigasin-6 {ECO:0000303|Ref.2};
DE   Flags: Precursor;
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19640306; DOI=10.1186/1471-2164-10-341;
RA   Fleury E., Huvet A., Lelong C., de Lorgeril J., Boulo V., Gueguen Y.,
RA   Bachere E., Tanguy A., Moraga D., Fabioux C., Lindeque P., Shaw J.,
RA   Reinhardt R., Prunet P., Davey G., Lapegue S., Sauvage C., Corporeau C.,
RA   Moal J., Gavory F., Wincker P., Moreews F., Klopp C., Mathieu M.,
RA   Boudry P., Favrel P.;
RT   "Generation and analysis of a 29,745 unique Expressed Sequence Tags from
RT   the Pacific oyster (Crassostrea gigas) assembled into a publicly accessible
RT   database: the GigasDatabase.";
RL   BMC Genomics 10:341-341(2009).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 31-38 AND 198-205, AND TISSUE SPECIFICITY.
RC   TISSUE=Shell {ECO:0000269|Ref.2};
RA   Marie B., Zanella-Cleon I., Becchi M., Marin F.;
RT   "Proteomic identification of novel proteins from the calcifying shell
RT   matrix of the Pacific oyster Crassostrea gigas.";
RL   FEBS Lett. 0:0-0(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Component of the organic matrix of calcified shell
CC       layers. {ECO:0000269|Ref.2}.
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DR   EMBL; CU992451; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P86789; -.
DR   SMR; P86789; -.
DR   PRIDE; P86789; -.
DR   HOGENOM; CLU_020027_14_3_1; -.
DR   Proteomes; UP000005408; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; -; 1.
DR   InterPro; IPR001466; Beta-lactam-related.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   Pfam; PF00144; Beta-lactamase; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..302
FT                   /note="Gigasin-6"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000403311"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  34106 MW;  C179CBA2D68C2178 CRC64;
     MSSRNLLYSS VVLFLVLFYC HGGPLEDRVR STIQEVYKNC RKDKNPGVIV SVVKDGQNVL
     TEALGVKDKI SGEAITTDTL FGLGGISALF ANILIAKKNA EYAEMDEDTT LRNLFGNNKL
     FEKSKLRSRY ATSLDVMAHR LGFKNTPHLF LDDTVTRGDP VIQRISSMKP RGRFRDSFYY
     NELTYSILTT IGERLGRDSW ENLVKNEIYT PLGMAKSKFF TTLDPSTVDI ARAYKEDDGS
     LFPVPFEFLK KWSSLCSTTC VLSSANDMSK FMNYLLGQRK PSWTKPCVTG PRKFTLILFD
     AI