ID   GIGAN_ORYSJ             Reviewed;        1160 AA.
AC   Q9AWL7; Q0JQ44; Q5VR72; Q5VR73; Q9SMB2;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Protein GIGANTEA;
GN   Name=GI; OrderedLocusNames=Os01g0182600, LOC_Os01g08700;
GN   ORFNames=P0666G04.27-1, P0666G04.27-2;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 185-1160 (ISOFORM 1).
RX   PubMed=10469647; DOI=10.1093/emboj/18.17.4679;
RA   Fowler S., Lee K., Onouchi H., Samach A., Richardson K., Morris B.,
RA   Coupland G., Putterill J.;
RT   "GIGANTEA: a circadian clock-controlled gene that regulates photoperiodic
RT   flowering in Arabidopsis and encodes a protein with several possible
RT   membrane-spanning domains.";
RL   EMBO J. 18:4679-4688(1999).
RN   [7]
RP   INDUCTION.
RX   PubMed=12040096; DOI=10.1093/pcp/pcf059;
RA   Hayama R., Izawa T., Shimamoto K.;
RT   "Isolation of rice genes possibly involved in the photoperiodic control of
RT   flowering by a fluorescent differential display method.";
RL   Plant Cell Physiol. 43:494-504(2002).
RN   [8]
RP   FUNCTION.
RX   PubMed=12700762; DOI=10.1038/nature01549;
RA   Hayama R., Yokoi S., Tamaki S., Yano M., Shimamoto K.;
RT   "Adaptation of photoperiodic control pathways produces short-day flowering
RT   in rice.";
RL   Nature 422:719-722(2003).
CC   -!- FUNCTION: Involved in regulation of circadian rhythm, and in the
CC       control of the photoperiodic flowering. Acts as suppressor of flowering
CC       under short-day (SD) and long-day (LD) conditions. Activates
CC       Hd1/CONSTANS gene. {ECO:0000269|PubMed:12700762}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9AWL7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9AWL7-2; Sequence=VSP_013910;
CC   -!- INDUCTION: Expressed with a circadian rhythm with the highest level 8
CC       hours into the light and the lowest level at dawn. The peak of
CC       expression in long days is slightly lower, shifted later and the
CC       decrease is slower. {ECO:0000269|PubMed:12040096}.
CC   -!- SIMILARITY: Belongs to the GIGANTEA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD68053.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP003047; BAD68052.1; -; Genomic_DNA.
DR   EMBL; AP003047; BAD68053.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008207; BAF04134.1; -; Genomic_DNA.
DR   EMBL; AP014957; BAS70743.1; -; Genomic_DNA.
DR   EMBL; AK067038; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AJ133787; CAB56058.1; -; mRNA.
DR   RefSeq; XP_015649578.1; XM_015794092.1. [Q9AWL7-1]
DR   RefSeq; XP_015649583.1; XM_015794097.1. [Q9AWL7-1]
DR   RefSeq; XP_015649590.1; XM_015794104.1. [Q9AWL7-1]
DR   RefSeq; XP_015649597.1; XM_015794111.1. [Q9AWL7-1]
DR   RefSeq; XP_015649603.1; XM_015794117.1. [Q9AWL7-1]
DR   RefSeq; XP_015649609.1; XM_015794123.1.
DR   AlphaFoldDB; Q9AWL7; -.
DR   STRING; 4530.OS01T0182600-03; -.
DR   PaxDb; Q9AWL7; -.
DR   PRIDE; Q9AWL7; -.
DR   EnsemblPlants; Os01t0182600-01; Os01t0182600-01; Os01g0182600. [Q9AWL7-1]
DR   EnsemblPlants; Os01t0182600-03; Os01t0182600-03; Os01g0182600. [Q9AWL7-1]
DR   GeneID; 4325329; -.
DR   Gramene; Os01t0182600-01; Os01t0182600-01; Os01g0182600. [Q9AWL7-1]
DR   Gramene; Os01t0182600-03; Os01t0182600-03; Os01g0182600. [Q9AWL7-1]
DR   KEGG; osa:4325329; -.
DR   eggNOG; ENOG502QU75; Eukaryota.
DR   HOGENOM; CLU_283623_0_0_1; -.
DR   InParanoid; Q9AWL7; -.
DR   OMA; EDYDSGM; -.
DR   OrthoDB; 68554at2759; -.
DR   PlantReactome; R-OSA-8933811; Circadian rhythm.
DR   PlantReactome; R-OSA-8934036; Long day regulated expression of florigens.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   Genevisible; Q9AWL7; OS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   GO; GO:0042752; P:regulation of circadian rhythm; IBA:GO_Central.
DR   GO; GO:0048586; P:regulation of long-day photoperiodism, flowering; IBA:GO_Central.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   InterPro; IPR026211; GIGANTEA.
DR   PANTHER; PTHR36319; PTHR36319; 1.
DR   PRINTS; PR02081; GIGANTEA.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Biological rhythms; Developmental protein;
KW   Differentiation; Flowering; Nucleus; Reference proteome.
FT   CHAIN           1..1160
FT                   /note="Protein GIGANTEA"
FT                   /id="PRO_0000087490"
FT   REGION          158..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          600..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          800..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         278..959
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_013910"
FT   CONFLICT        701
FT                   /note="Missing (in Ref. 5; AK067038)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1149
FT                   /note="Missing (in Ref. 6; CAB56058)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1160 AA;  127067 MW;  F2422C69B5B5C6E3 CRC64;
     MSASNEKWID GLQFSSLFWP PPQDSQQKQA QILAYVEYFG QFTADSEQFP EDIAQLIQSC
     YPSKEKRLVD EVLATFVLHH PEHGHAVVHP ILSRIIDGTL SYDRNGFPFM SFISLFSHTS
     EKEYSEQWAL ACGEILRVLT HYNRPIFKVD HQHSEAECSS TSDQASSCES MEKRANGSPR
     NEPDRKPLRP LSPWITDILL AAPLGIRSDY FRWCGGVMGK YAAGGELKPP TTAYSRGSGK
     HPQLMPSTPR WAVANGAGVI LSVCDEEVAR YETANLTAAA VPALLLPPPT TPLDEHLVAG
     LPPLEPYARL FHRYYAIATP SATQRLLFGL LEAPPSWAPD ALDAAVQLVE LLRAAEDYDS
     GMRLPKNWMH LHFLRAIGTA MSMRAGIAAD TSAALLFRIL SQPTLLFPPL RHAEGVELHH
     EPLGGYVSSY KRQLEVPASE ATIDATAQGI ASMLCAHGPD VEWRICTIWE AAYGLLPLSS
     SAVDLPEIVV AAPLQPPTLS WSLYLPLLKV FEYLPRGSPS EACLMRIFVA TVEAILRRTF
     PSETSEQSRK PRSQSKNLAV AELRTMIHSL FVESCASMDL ASRLLFVVLT VCVSHQALPG
     GSKRPTGSDN HSSEEVTNDS RLTNGRNRCK KRQGPVATFD SYVLAAVCAL SCELQLFPFI
     SKNGNHSNLK DSIKIVIPGK TTGISNELHN SISSAILHTR RILGILEALF SLKPSSVGTS
     WSYSSNEIVA AAMVAAHVSE LFRRSRPCLN ALSALKQCKW DAEISTRASS LYHLIDLHGK
     TVTSIVNKAE PLEAHLTLTP VKKDEPPIEE KNINSSDGGA LEKKDASRSH RKNGFARPLL
     KCAEDVILNG DVASTSGKAI ASLQVEASDL ANFLTMDRNG GYRGSQTLLR SVLSEKQELC
     FSVVSLLWQK LIASPEMQMS AESTSAHQGW RKVVDALCDI VSASPTKASA AIVLQAEKDL
     QPWIARDDEQ GQKMWRVNQR IVKLIAELMR NHDSPEALVI LASASDLLLR ATDGMLVDGE
     ACTLPQLELL EVTARAVHLI VEWGDSGVSV ADGLSNLLKC RLSTTIRCLS HPSAHVRALS
     MSVLRDILNS GQINSSKLIQ GEHRNGIQSP TYQCLAASII NWQADVERCI EWEAHSRRAT
     GLTLAFLTAA AKELGCPLTC