GIMA9_MOUSE
ID GIMA9_MOUSE Reviewed; 291 AA.
AC G3X987; Q4V9U6; Q8CGH1;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=GTPase IMAP family member 9;
DE AltName: Full=Immune-associated nucleotide-binding protein 7;
DE Short=IAN-7;
DE AltName: Full=Immunity-associated nucleotide-binding protein 7;
GN Name=Gimap9; Synonyms=Ian7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Liver, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=16509771; DOI=10.1371/journal.pbio.0040103;
RA Nitta T., Nasreen M., Seike T., Goji A., Ohigashi I., Miyazaki T., Ohta T.,
RA Kanno M., Takahama Y.;
RT "IAN family critically regulates survival and development of T
RT lymphocytes.";
RL PLoS Biol. 4:593-605(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed in thymus (in thymocytes), spleen (in
CC splenocytes), lymph node and lung. {ECO:0000269|PubMed:16509771}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH38043.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AC153894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466597; EDK98559.1; -; Genomic_DNA.
DR EMBL; BC038043; AAH38043.1; ALT_SEQ; mRNA.
DR EMBL; BC096680; AAH96680.1; -; mRNA.
DR CCDS; CCDS20109.1; -.
DR RefSeq; NP_777620.1; NM_174960.2.
DR AlphaFoldDB; G3X987; -.
DR SMR; G3X987; -.
DR STRING; 10090.ENSMUSP00000050330; -.
DR iPTMnet; G3X987; -.
DR PhosphoSitePlus; G3X987; -.
DR EPD; G3X987; -.
DR MaxQB; G3X987; -.
DR PaxDb; G3X987; -.
DR PRIDE; G3X987; -.
DR ProteomicsDB; 341391; -.
DR DNASU; 317758; -.
DR Ensembl; ENSMUST00000054050; ENSMUSP00000050330; ENSMUSG00000051124.
DR GeneID; 317758; -.
DR KEGG; mmu:317758; -.
DR UCSC; uc009bvh.1; mouse.
DR CTD; 317758; -.
DR MGI; MGI:3511744; Gimap9.
DR VEuPathDB; HostDB:ENSMUSG00000051124; -.
DR eggNOG; ENOG502R7PE; Eukaryota.
DR GeneTree; ENSGT00940000163384; -.
DR HOGENOM; CLU_010468_0_0_1; -.
DR InParanoid; G3X987; -.
DR OMA; CEIAEAQ; -.
DR OrthoDB; 1108753at2759; -.
DR PhylomeDB; G3X987; -.
DR TreeFam; TF330845; -.
DR BioGRID-ORCS; 317758; 3 hits in 72 CRISPR screens.
DR PRO; PR:G3X987; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; G3X987; protein.
DR Bgee; ENSMUSG00000051124; Expressed in thymus and 134 other tissues.
DR ExpressionAtlas; G3X987; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005811; C:lipid droplet; ISO:MGI.
DR GO; GO:0005525; F:GTP binding; ISO:MGI.
DR GO; GO:0003924; F:GTPase activity; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0046039; P:GTP metabolic process; ISO:MGI.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903; PTHR10903; 1.
DR Pfam; PF04548; AIG1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51720; G_AIG1; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..291
FT /note="GTPase IMAP family member 9"
FT /id="PRO_0000447245"
FT DOMAIN 6..208
FT /note="AIG1-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 15..22
FT /note="G1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 42..46
FT /note="G2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 63..66
FT /note="G3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 132..135
FT /note="G4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 168..170
FT /note="G5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT BINDING 17..23
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
FT BINDING 37
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
FT BINDING 133..135
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
FT BINDING 169
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8NHV1"
FT CONFLICT 27
FT /note="T -> I (in Ref. 3; AAH96680)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 291 AA; 33298 MW; 9C69A142546668D9 CRC64;
MAGQGDTEVR IILVGKTGNG KSATANTILG RRQFDSKICA NAVTKTCQRA YREWKGKNLV
VVDTPGLFDT KETMKTTCFE ISRCVLYSCP GPHAIILVLR LDRYTEEEQK TVALIKGLFG
EAALKYMIIL FTHKEDLEDQ SLDNFVSDAG EKLNNIISQC GKRYLAFNNK AALDEQENQV
QQLIELTEKM VAQNGGSYFS DKIYKDIDSR LNHCLEELKE TYAQQLTSEI ERIEKEYAAK
LEKGKAAQIV FAQRNHDEKL RNLKEKAEET VFMYIFQKIK EILSKLWDEL W
