ID   GIMD1_HUMAN             Reviewed;         217 AA.
AC   P0DJR0;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=GTPase IMAP family member GIMD1;
DE   AltName: Full=GIMAP family P-loop NTPase domain-containing protein 1;
GN   Name=GIMD1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-146.
RA   Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT   "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT   human.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC       IAN subfamily. {ECO:0000305}.
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DR   EMBL; AC093680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DN831977; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS82942.1; -.
DR   RefSeq; NP_001182067.1; NM_001195138.1.
DR   AlphaFoldDB; P0DJR0; -.
DR   SMR; P0DJR0; -.
DR   iPTMnet; P0DJR0; -.
DR   PhosphoSitePlus; P0DJR0; -.
DR   BioMuta; GIMD1; -.
DR   DMDM; 408407619; -.
DR   MassIVE; P0DJR0; -.
DR   PeptideAtlas; P0DJR0; -.
DR   PRIDE; P0DJR0; -.
DR   DNASU; 100507096; -.
DR   Ensembl; ENST00000507153.2; ENSP00000489975.1; ENSG00000250298.6.
DR   Ensembl; ENST00000638719.4; ENSP00000491450.2; ENSG00000250298.6.
DR   GeneID; 100507096; -.
DR   KEGG; hsa:100507096; -.
DR   MANE-Select; ENST00000638719.4; ENSP00000491450.2; NM_001195138.2; NP_001182067.1.
DR   CTD; 100507096; -.
DR   DisGeNET; 100507096; -.
DR   GeneCards; GIMD1; -.
DR   HGNC; HGNC:44141; GIMD1.
DR   HPA; ENSG00000250298; Tissue enriched (intestine).
DR   neXtProt; NX_P0DJR0; -.
DR   OpenTargets; ENSG00000250298; -.
DR   VEuPathDB; HostDB:ENSG00000250298; -.
DR   GeneTree; ENSGT00530000069080; -.
DR   InParanoid; P0DJR0; -.
DR   OMA; WKDFTAV; -.
DR   BioGRID-ORCS; 100507096; 12 hits in 188 CRISPR screens.
DR   Pharos; P0DJR0; Tdark.
DR   PRO; PR:P0DJR0; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; P0DJR0; protein.
DR   Bgee; ENSG00000250298; Expressed in duodenum and 9 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR006703; G_AIG1.
DR   InterPro; IPR045058; GIMA/IAN/Toc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10903; PTHR10903; 1.
DR   Pfam; PF04548; AIG1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51720; G_AIG1; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..217
FT                   /note="GTPase IMAP family member GIMD1"
FT                   /id="PRO_0000419199"
FT   DOMAIN          6..217
FT                   /note="AIG1-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT   BINDING         15..23
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         36
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         148..150
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  24463 MW;  AAC33C2D1A799989 CRC64;
     MTDPNKMIIN LALFGMTQSG KSSAGNILLG STDFHSSFAP CSVTTCCSLG RSCHLHSFMR
     RGGLEVALQV QVLDTPGYPH SRLSKKYVKQ EVKEALAHHF GQGGLHLALL VQRADVPFCG
     QEVTDPVQMI QELLGHAWMN YTAILFTHAE KIEEAGLTED KYLHEASDTL KTLLNSIQHK
     YVFQYKKGKS LNEQRMKILE RIMEFIKENC YQVLTFK