GIN1_MOUSE
ID GIN1_MOUSE Reviewed; 518 AA.
AC Q8K259; Q3TEY8; Q3V2V3; Q8C3X6; Q9CXB6; Q9D5K2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Gypsy retrotransposon integrase-like protein 1;
DE Short=GIN-1;
DE AltName: Full=Zinc finger H2C2 domain-containing protein;
GN Name=Gin1; Synonyms=Zh2c2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Amnion, Heart, Lung, Testis, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8K259-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K259-2; Sequence=VSP_033440;
CC Name=3;
CC IsoId=Q8K259-3; Sequence=VSP_033441, VSP_033442;
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DR EMBL; AK015243; BAB29761.1; -; mRNA.
DR EMBL; AK018404; BAB31197.1; -; mRNA.
DR EMBL; AK084620; BAC39232.1; -; mRNA.
DR EMBL; AK090002; BAE43402.1; -; mRNA.
DR EMBL; AK169361; BAE41110.1; -; mRNA.
DR EMBL; BC033572; AAH33572.1; -; mRNA.
DR CCDS; CCDS35679.1; -. [Q8K259-1]
DR CCDS; CCDS78662.1; -. [Q8K259-2]
DR RefSeq; NP_001297702.1; NM_001310773.1. [Q8K259-2]
DR RefSeq; NP_080526.2; NM_026250.3. [Q8K259-1]
DR AlphaFoldDB; Q8K259; -.
DR STRING; 10090.ENSMUSP00000108464; -.
DR PhosphoSitePlus; Q8K259; -.
DR EPD; Q8K259; -.
DR MaxQB; Q8K259; -.
DR PaxDb; Q8K259; -.
DR PeptideAtlas; Q8K259; -.
DR PRIDE; Q8K259; -.
DR ProteomicsDB; 267796; -. [Q8K259-1]
DR ProteomicsDB; 267797; -. [Q8K259-2]
DR ProteomicsDB; 267798; -. [Q8K259-3]
DR Antibodypedia; 48162; 61 antibodies from 14 providers.
DR DNASU; 252876; -.
DR Ensembl; ENSMUST00000027571; ENSMUSP00000027571; ENSMUSG00000026333. [Q8K259-2]
DR Ensembl; ENSMUST00000112842; ENSMUSP00000108461; ENSMUSG00000026333. [Q8K259-3]
DR Ensembl; ENSMUST00000112844; ENSMUSP00000108464; ENSMUSG00000026333. [Q8K259-1]
DR GeneID; 252876; -.
DR KEGG; mmu:252876; -.
DR UCSC; uc007cfm.1; mouse. [Q8K259-3]
DR UCSC; uc007cfn.1; mouse. [Q8K259-1]
DR UCSC; uc011wpx.1; mouse. [Q8K259-2]
DR CTD; 54826; -.
DR MGI; MGI:2182036; Gin1.
DR VEuPathDB; HostDB:ENSMUSG00000026333; -.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT00940000160670; -.
DR HOGENOM; CLU_040181_0_0_1; -.
DR InParanoid; Q8K259; -.
DR OMA; FQSEWIG; -.
DR OrthoDB; 583605at2759; -.
DR PhylomeDB; Q8K259; -.
DR TreeFam; TF352301; -.
DR BioGRID-ORCS; 252876; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8K259; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8K259; protein.
DR Bgee; ENSMUSG00000026333; Expressed in spermatocyte and 225 other tissues.
DR ExpressionAtlas; Q8K259; baseline and differential.
DR Genevisible; Q8K259; MM.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..518
FT /note="Gypsy retrotransposon integrase-like protein 1"
FT /id="PRO_0000333018"
FT DOMAIN 130..292
FT /note="Integrase catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT MOD_RES 498
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NXP7"
FT VAR_SEQ 112..200
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033440"
FT VAR_SEQ 113..118
FT /note="YACQHC -> WLPRRA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033441"
FT VAR_SEQ 119..518
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033442"
FT CONFLICT 60
FT /note="N -> S (in Ref. 1; BAE43402)"
FT /evidence="ECO:0000305"
FT CONFLICT 216
FT /note="V -> I (in Ref. 2; AAH33572)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="K -> Q (in Ref. 1; BAE43402)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 518 AA; 58789 MW; 39C01732FE469835 CRC64;
MVRSGKNGDL HLKQIAYYKR TGEYHPTTLP SERSGIRRAA KKFVFKEKKL FYVGKDRKQN
RLVVVSEEEK KKVLRECHEN GPGVHHGISR TLTLVESGYY WTSVTNDVKQ WVYACQHCQV
AKNTVIVAPQ QHLPMVGNPW SVVTVDLMGP FHTSNRSHVY AIIMTDLFTK WVMILPLCDV
SASEISKAII NIFFLYGPPQ KIIMDQRDEF IEQINVELYR LFGAKEIVIS RASGSVNPAE
NTPSTIKTFL SKHCADHPNS WDEHLPALSF AFNVTHLEPN KNTPYFQMFN RNPCVLECPP
EEGSEGTSVF ARIVAAIREA DGVVENKTPA SSQMENNNSD ELSKSKVVKK KAKQLNPFHL
KVGHEVLRQR KNWWKDGRFQ SEWVGPCVID YITESGCAVL RDNTGTRLKR PIKMSHLRPY
VRESSEQDSL YLLQGSIVAD HDYIGLPEIP VGTYQANILV EDATIGIADN ELLISSKDHE
LLEYRNSKIS ALVEDHSSLE KQTFSLLDSS NQVLEYLS
